ESM1

ESM1 encodes Endothelial cell-specific molecule 1, also known as Endocan. It is a soluble proteoglycan mainly secreted by vascular endothelial cells. Acting as a key regulator of cell adhesion and migration, Endocan interacts with extracellular matrix proteins and cell surface receptors. It is involved in the PI3K - AKT and MAPK signaling pathways, which are crucial for cell survival and proliferation.
Dysregulation of ESM1 is linked to various diseases, such as cancer, cardiovascular disorders and inflammatory diseases. In cancer, it promotes tumor angiogenesis and metastasis. Currently, several research efforts are underway to develop therapeutic agents targeting ESM1 for potential cancer treatment, aiming to block its function and inhibit disease progression.

Popular Product:

ESM1 Antibody (CSB-PA007825LA01HU)

Validated Data

IHC image of CSB-PA007825LA01HU diluted at 1:400 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Human endothelial cell-specific molecule 1(ESM-1) ELISA Kit (CSB-E16530h)

Validated Data

Code: CSB-E16530h

Size: 96T,5×96T,10×96T

Sensitivity: 0.78 ng/ml

Detection Range: 3.12 ng/ml-200 ng/ml.

These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

The following ESM1 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

ESM1 Antibodies

ESM1 Proteins

ESM1 ELISA Kits

ESM1 Antibodies

ESM1 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA007825LA01HU	ESM1 Antibody	Human	ELISA, IHC
CSB-PA007825LC01HU	ESM1 Antibody, FITC conjugated	Human
CSB-PA007825HA01HU	ESM1 Antibody	Human	ELISA, IHC
CSB-PA007825HB01HU	ESM1 Antibody, HRP conjugated	Human	ELISA
CSB-PA007825HD01HU	ESM1 Antibody, Biotin conjugated	Human	ELISA

ESM1 Proteins

ESM1 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-YP007825HU CSB-EP007825HU CSB-BP007825HU CSB-MP007825HU CSB-EP007825HU-B	Recombinant Human Endothelial cell-specific molecule 1 (ESM1)	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

ESM1 ELISA Kit

ESM1 ELISA Kit for Homo sapiens (Human)

Code	Product Name	Sample Types	Sensitivity
CSB-E16530h	Human endothelial cell-specific molecule 1(ESM-1) ELISA Kit	serum, plasma, tissue homogenatess.	0.78 ng/ml

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