Recombinant Human Insulin-like growth factor-binding protein 2 (IGFBP2)

1. Following IGFBP2 knockdown using rAAV2-ZsGreen-shRNA-hIGFBP2, matrix metalloproteinase2 expression was significantly reduced in tumor tissues compared with that in rAAV2ZsGreenshRNAscramble treated tumor tissues. PMID: 29344663
2. IGFBP2 overexpression increased the expression of p-p65 and nuclear p65, while IGFBP2 knockdown reduced the expression of p-p65 and nuclear p65. PMID: 29228449
3. The associated effects appear to be mediated by inhibition of IGFBP-2 expression and stimulation of p21 expression. This suggests that simulated microgravity might represent a promising method to discover new targets for glioma therapeutic strategy. PMID: 28707224
4. these results suggest that IGFBP2 plays an important role in promoting tumorigenesis, through estrogen and ERalpha signaling pathway. PMID: 28410230
5. patients with low IGFBP2 expressiondisplay a clear advantage in overall and disease-free survival, whereas those with high IGFBP2 expressionhave worse median survival than IDH-wildtype patients. PMID: 27852048
6. The interaction of IGFBP2 and p63 might account for the pathogenesis of rhabdomyosarcoma tumors. PMID: 28129571
7. Co-ordinated and reciprocal alteration in IGFBP-2 and -5 expression may play a role in the acquisition of endocrine resistance in breast cancer. PMID: 27050076
8. We verified that NFIA binds to the IGFBP2 promoter and transcriptionally enhances IGFBP2 expression levels. We identified that NFIA-mediated IGFBP2 signaling pathways are involved in miR-302b-induced glioma cell death. PMID: 28323865
9. Insulin-like growth factor binding protein 2 potentiates glioblastoma tumor growth by the activation of the beta-catenin pathway through its C-terminal domain, and their coexpression possibly contributes to worse patient prognosis. PMID: 27044294
10. mechanistic investigations defined insulin-like growth factor binding protein 2 (IGFBP2)as a direct and functional downstream target of microRNA-592, which was involved in the microRNA-592-mediated tumor-suppressive effects in glioma cells. PMID: 28718372
11. IGFBP2 and IGFBP3 may serve as compensatory biomarkers for CA19-9. Early diagnosis with this marker combination may improve the prognosis of invasive ductal adenocarcinoma of pancreas patients. PMID: 27579675
12. In human whole blood cells, methylation of IGFBP2 at the homologous CpG site was increased in obese men with impaired glucose tolerance. In conclusion, our data show that increased methylation of hepatic Igfbp2 during infancy predicts the development of fatty liver later in life and is linked to deterioration of glucose metabolism. PMID: 27126637
13. Data suggest that circulating insulin-like growth factor-binding protein 2 (IGFBP2) has potential as a biomarker predicting prognosis for gastric cancer patients. PMID: 28036255
14. Together, this study validated that T-2 toxin exposure might promote the progression of KBD by inducing chondrocyte injury, suppressing matrix synthesis and accelerating cellular catabolism through IGFBP2. Therefore, this research will elucidate a new insight about how T-2 toxin participate in the pathogenesis of KBD. PMID: 27416762
15. IGFBP2 protein levels are altered in type 2 diabetes mellitus patients and associated with cardiovascular disease risk factors. PMID: 28179448
16. The monoclonal gammopathy of undetermined significance and multiple myeloma patients displayed a significant increase in intact IGFBP-2 and decrease in intact IGFBP-3 in the circulation compared to control individuals. PMID: 27111220
17. In patients with malignant and borderline ovarian tumors, the level of IGFBP-2 was higher than in healthy women and in patients with benign ovarian tumors. PMID: 27165066
18. IGFBP2 and SOCS3 were up-regulated in Kashin-Beck disease chondrocytes and decreased with increasing selenium concentrations. IGFBP2 expressed highest in the middle zone of KBD cartilage, SOCS3 expressed higher in the middle and deep zone. IGFBP2 and SOCS3 may be the biomarkers for KBD diagnosis and evaluating the effect of selenium supplement. PMID: 27099071
19. There was a positive correlation between the IGFBP2 levels of and those of inflammatory mediators in HIV Infections. PMID: 25890304
20. IGFBP-2 overexpression in HUVECs promoted endothelial progenitor cells(EPC)-endothelial adhesion. The RGD motif in its C-domain is required for interaction with integrin alpha5beta1. PMID: 26076738
21. Serum IGFBP2 reflects disease activity and renal pathology changes in lupus nephritis. PMID: 26616478
22. Data show that modulation of insulin like growth factor binding protein 2 (IGFBP2) expression affects proliferation, motility, and chemosensitization of eophageal adenocarcinoma (EAC) cells in a serum-dependent manner. PMID: 26317790
23. Identification of a novel tumor-promoting function for IGFBP2 of activating EGFR/STAT3 signaling and facilitating EGFR accumulation in the nucleus, thereby deregulating EGFR signaling by two distinct mechanisms. PMID: 25893308
24. that age-specific cognitive decline may be moderated by IGF-BP2 PMID: 26043140
25. Serum IGFBP2 was increased in patients with hepatocellular carcinoma compared to healthy controls, but lower than in patients with liver cirrhosis. PMID: 26068014
26. The expression levels of maspin were lower in the cisplatin-resistant tissue and cells, and was enhanced by IGFBP-2 inhibition. PMID: 26080829
27. Insulin-like growth factor binding protein 2 is strongly associated with restoration of keratocyte phenotype in HCFs. PMID: 26559475
28. Elevated serum IGFBP2 levels might play a role in the postnatal growth retardation phenotype of Pallister-Killian syndrome. PMID: 25900123
29. IGFBP-2 secreted by mature adipocytes plays a key role in promoting the metastatic ability of MCF-7 breast cancer cells PMID: 25747684
30. These results implicate TRIB3 and IGFBP2, both of which are known to be overexpressed in several types of cancers, as pro-survival modulators of cell viability in nutrient-deficient microenvironments. PMID: 26094770
31. IGFBP-2 may have a role in metabolic syndrome and is independently associated with VLDL triglycerides PMID: 25463100
32. Report changes in serum levels of protein molecular forms of insulin-like growth factor binding protein-2 with age. PMID: 25106097
33. Low IGFBP2 expression is associated with adrenocortical carcinoma. PMID: 24833102
34. Elevated plasma IGFBP-2 levels after combined postoperative radiotherapy and chemotherapy in elderly glioblastoma patients correlate with poor Karnofsky performance status score and predicts poor prognosis. PMID: 24690948
35. The amount of IGFBP-2 monomer increased in sera from all studied patients compared to controls, whereas the amount of IGFBP-2/alpha2M complexes most often decreased, being significantly reduced in patients with pancreas, colon, breast or ovary tumor. PMID: 25746666
36. A combined profile of preoperative IGFBP-2, GFAP, and YKL-40 plasma levels could serve as an additional diagnostic tool for patients with inoperable brain lesions suggestive of Glioblastoma multiforme. PMID: 25139333
37. Constitutive IGFBP2 downregulation may represent a novel mechanism for acquired resistance to IGF1R therapeutic antibody in vivo. PMID: 24292683
38. Serum IGFBP2 and MSLN are weak diagnostic classifiers individually, but may be useful in a diagnostic biomarker panel for pancreatic cancer. PMID: 24308545
39. two IGFBP2 heparin-binding domains contribute differentially to 2- or 3-carbon O-sulfated glycosaminoglycans binding in free IGFBP2 and the IGF2/IGFBP2 protein complex. PMID: 24604839
40. Increased serum concentration significantly and independently associated with long-term cardiovascular disease mortality in patients with lower-extremity peripheral artery disease PMID: 24548188
41. Exogenous IGFBP-2 induces proliferation, invasion, and chemoresistance in glioma cells via integrin-beta1/ERK signaling. PMID: 25093489
42. IGFBP2 is a critical cell-autonomous factor that promotes the survival and migration of acute leukemia cells. PMID: 24191913
43. insulin-like growth factors bound to IGFBP-3 remain in the circulation, whereas those bound to IGFBP-2 freely reach target tissues. PMID: 24051179
44. High IGFBP-2 gene expression is asssociated with cytomegalovirus positive glioblastoma multiforme. PMID: 24352760
45. the IGFBP2/FAK pathway is causally associated with dasatinib resistance. PMID: 24130049
46. IGFBP2 overexpression is associated with metastasis and poor survival in NSCLC patients. PMID: 24682597
47. Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival. PMID: 24069370
48. IGFBP-2 in complex with alpha2 macroglobulin was 2.5 times lower in cancer patients. PMID: 24275430
49. IGFBP-2 possesses a functional nuclear localization signal sequence and IGFBP-2 actively translocates into the nucleus by a classical nuclear import mechanism, involving formation of IGFBP-2 complexes with importin-alpha. PMID: 23435424
50. Increased glucose concentrations inhibited the efficacy of docetaxel at inducing apoptosis, which was associated with increased IGFBP2 production as a result of glucose-induced acetylation of histones bound to the IGFBP2 promoter. PMID: 23959956

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HGNC: 5471

OMIM: 146731

KEGG: hsa:3485

STRING: 9606.ENSP00000233809

UniGene: Hs.438102