IGFBP2

IGFBP2, or insulin-like growth factor binding protein 2, is a multifaceted protein encoded by the IGF-BP2 gene and found across various cellular and tissue types. This protein primarily modulates cellular activities by binding to insulin-like growth factors (IGFs), thereby controlling bioavailability and impacting cell growth, differentiation, and apoptosis. IGF-BP2 also influences the cell cycle, inhibiting proliferation, and plays roles in cell migration, tissue repair, and tumorigenesis. Its aberrant expression is often linked to numerous diseases, particularly in oncology, where increased levels of IGF-BP2 are correlated with tumor aggressiveness and unfavorable outcomes, highlighting its potential as a therapeutic target in cancer research.