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| Code | CSB-EP011047HU |
| Product Type | Recombinant Protein |
| Size | US$1726 |
| Uniprot No. | P48551 |
| Relevance | Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. |
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| Storage Buffer | Tris-based buffer,50% glycerol |
| Alias | Interferon alpha binding protein;Type I interferon receptor 2 |
| Species | Homo sapiens (Human) |
| Purity | Greater than 90% as determined by SDS-PAGE. |
| Sequence | ISYDSPDYTDESCTFKISLRNFRSILSWELKNHSIVPTHYTLLYTIMSKPEDLKVVKNCANTTRSFCDLTDEWRSTHEAYVTVLEGFSGNTTLFSCSHNFWLAIDMSFEPPEFEIVGFTNHINVMVKFPSIVEEELQFDLSLVIEEQSEGIVKKHKPEIKGNMSGNFTYIIDKLIPNTNYCVSVYLEHSDEQAVIKSPLKCTLLPPGQESESAESAK |
| Research Area | Epigenetics and Nuclear Signaling |
| Source | E.coli |
| Gene Names | IFNAR2 |
| Expression Region | 27-243aa |
| Tag Info | N-terminal 6xHis-SUMO-tagged |
| Mol. Weight | 40.8kDa |
| Protein Description | Partial |
| Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
| Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
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| Function | Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation |
| Involvement in disease | Immunodeficiency 45 (IMD45) |
| Subcellular Location | Isoform 1: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 2: Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Isoform 3: Secreted |
| Protein Families | Type II cytokine receptor family |
| Tissue Specificity | Isoform 3 is detected in the urine (at protein level) (PubMed:8181059, PubMed:7759950). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. |
| Database Links |
HGNC: 5433 OMIM: 602376 KEGG: hsa:3455 STRING: 9606.ENSP00000343957 UniGene: Hs.708195 |
| Pathway |
Jak-STAT signaling pathway
PI3K-Akt signaling pathway Necroptosis Natural killer cell mediated cytotoxicity NOD-like receptor signaling pathway Osteoclast differentiation Toll-like receptor signaling pathway |
IFNAR2 Antibodies for Homo sapiens (Human)
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA011047GA01HU | IFNAR2 Antibody | Human | ELISA,WB |
| CSB-PA11439B0Rb | IFNAR2 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11439C0Rb | IFNAR2 Antibody, FITC conjugated | Human | ELISA |
| CSB-PA11439A0Rb | IFNAR2 Antibody | Human | ELISA, IHC |
| CSB-PA11439D0Rb | IFNAR2 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA005590 | IFNAR2 Antibody | Human | WB,ELISA |
IFNAR2 Antibodies for Human
| Code | Product Name | Species Reactivity | Application |
|---|---|---|---|
| CSB-PA011047ESR1HU | IFNAR2 Antibody | Human | ELISA, IHC |
| CSB-PA011047ESR2HU | IFNAR2 Antibody | Human | ELISA, WB, IHC |
IFNAR2 Proteins for Homo sapiens (Human)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP011047HU CSB-BP011047HU CSB-MP011047HU |
Recombinant Human Interferon alpha/beta receptor 2(IFNAR2),partial | Yeast Baculovirus Mammalian cell |
| CSB-RP114344h | Recombinant Human Interferon alpha/beta receptor 2(IFNAR2),partial | E.coli |
| CSB-CF011047HU(A4) | Recombinant Human Interferon alpha/beta receptor 2(IFNAR2) | in vitro E.coli expression system |
IFNAR2 ELISA Kit for Homo sapiens (Human)
| Code | Product Name | Sample Types | Sensitivity |
|---|---|---|---|
| CSB-EL011047HU | Human Interferon alpha/beta receptor 2(IFNAR2) ELISA kit | serum, plasma, tissue homogenates, cell culture supernates | 0.039 ng/mL |
Recombinant Human Bifunctional Epoxide hydrolase 2(EPHX2)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human Tyrosine-protein kinase JAK1(JAK1),partial
Express system: Yeast
Species: Homo sapiens (Human)
Recombinant Human Clathrin heavy chain 2(CLTCL1) ,partial
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Rat Dipeptidyl peptidase 4(Dpp4),partial
Express system: E.coli
Species: Rattus norvegicus (Rat)
Recombinant Human Arf-GAP with dual PH domain-containing protein 1(ADAP1)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Human TGFB1-induced anti-apoptotic factor 1(TIAF1)
Express system: E.coli
Species: Homo sapiens (Human)
Recombinant Epstein-Barr virus Latent membrane protein 1(LMP1),partial
Express system: Yeast
Species: Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
