Recombinant Human Interleukin-2(IL2)

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Code CSB-YP011629HU
Product Type Recombinant Protein
Size US$2010
Uniprot No. P60568
Relevance Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP011629HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) IL2.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP011629HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) IL2.
Storage Buffer Tris-based buffer,50% glycerol
Alias T-cell growth factor ;TCGFINN: Aldesleukin
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence APTSSSTKKTQLQLEHLLLDLQMILNGINNYKNPKLTRMLTFKFYMPKKATELKHLQCLEEELKPLEEVLNLAQSKNFHLRPRDLISNINVIVLELKGSETTFMCEYADETATIVEFLNRWITFCQSIISTLT
Research Area Immunology
Source Yeast
Gene Names IL2
Protein Names Recommended name: Interleukin-2 Short name= IL-2 Alternative name(s): T-cell growth factor Short name= TCGF INN= Aldesleukin
Expression Region 21-153aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 17.4kDa
Protein Description Full Length of Mature Protein
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Involvement in disease A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Subcellular Location Secreted
Protein Families IL-2 family
Database Links

HGNC: 6001

OMIM: 147680

KEGG: hsa:3558

STRING: 9606.ENSP00000226730

UniGene: Hs.89679

Pathway Jak-STAT signaling pathway
PI3K-Akt signaling pathway
T cell receptor signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation

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