Recombinant Human Mitogen-activated protein kinase kinase kinase 14 (MAP3K14), partial

1. A TRAF3-NIK axis differentially regulates viral DNA vs RNA pathways in innate immune signaling. PMID: 30018345
2. Data show that breast cancer stem cells (BCSCs) expressed higher levels of NF-kappaB-inducing kinase (NIK). PMID: 27876836
3. These findings highlight the importance of NIK in tumor pathogenesis and invite new therapeutic strategies that attenuate mitochondrial dysfunction through inhibition of NIK and Drp1. PMID: 27889261
4. results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100. PMID: 27678221
5. report a detailed state-of-the-art mass spectrometry-based protein-protein interaction network including the noncanonical NF-kappaB signaling nodes TRAF2, TRAF3, IKKalpha, NIK, and NF-kappaB2/p100; also provide a differential interactome of NIK mutants that cause immunodeficiency PMID: 27416764
6. OLFM1 is a negative regulator of non-canonical NF-kappaB signalling by interacting with and inhibiting NIK. Thus, OLFM1 may serve as a valuable biomarker and therapeutic target for colorectal cancer (CRC) patients. PMID: 27555280
7. The expression of OTUD7B and NIK were negatively correlated in non-small cell lung cancer tumor samples. the higher expression of NIK was related to more lymph node metastasis and later TNM stage. high OTUD7B/low NIK index can predict an good prognosis. PMID: 27499151
8. NIK expression was significantly increased in the tumor tissue of patients with breast carcinoma, which may be an important factor that affects the prognosis of these patients. PMID: 26823811
9. This study identified two novel independent loci (MAP3K14 and CARD9) strongly associated with joint damage in Mexican Americans and European Americans and a few shared loci showing suggestive evidence for association. PMID: 26498133
10. The forced expression of NDRG2 in ATL cells down-regulates not only the canonical pathway by inhibiting AKT signaling but also the non-canonical pathway by inducing NF-kappaB-inducing kinase (NIK) dephosphorylation via the recruitment of PP2A PMID: 26269411
11. NIK(+) endothelial cells may play an important role in the persistence of synovitis PMID: 26178280
12. Data suggest microRNA302c, but not microRNA520e, promotes replication of influenza A virus H3N2 although the two microRNAs target same site of NFkappaB-inducing kinase (MAP3K14) 3prime untranslated region; studies were conducted in lung epithelial cells. PMID: 26602079
13. by demonstrating a critical role of NIK in mediating NF-kappaB activation and BAG3 induction upon ST80/Bortezomib cotreatment, our study provides novel insights into mechanisms of resistance to proteotoxic stress in RMS PMID: 25766331
14. Loss-of-function mutations in NIK can cause B-cell lymphopenia, hypogammaglobulinemia, impaired ICOSL expression, and disordered T helper cell and NK cell function. PMID: 25406581
15. Membrane attack complexes activate noncanonical NF-kappaB by forming a novel Akt(+)NIK(+) signalosome on Rab5(+) endosomes. PMID: 26195760
16. Authors show that activation of NF-kappaB by Kaposi's sarcoma-associated herpesvirus K15 protein involves the recruitment of NF-kappaB-inducing kinase (NIK) and IKK alpha/beta to result in the phosphorylation of p65/RelA on Ser536. PMID: 25187543
17. NIK plays a key role in constitutive NF-kappaB activation and the progression of ovarian cancer cells PMID: 24533079
18. Identification and function of the NIK IAP binding motif, which promotes c-IAP1-dependent ubiquitylation of NIK. PMID: 25246529
19. These studies provide evidence for a role of NF-kappaB-inducing kinase (NIK) and subsequent non-canonical NF-kappaB signalling in pathological angiogenesis PMID: 25043127
20. Results show that nuclear factor-kappa B inducing kinase has a role in graft-versus-host disease by maintaining the viability of activated alloreactive T lymphocytes. PMID: 20823135
21. NIK is a new therapeutic target for Mantle cell lymphoma treatment, particularly for lymphomas that are refractory to B cell receptor pathway inhibitors. PMID: 24362935
22. A pivotal role for NIK in nuclear factor kappa B activation and regulation of gene expression in T-cell lymphoma. PMID: 23536439
23. TRAF2/NIK/NF-kappaB2 pathway regulates pancreatic ductal adenocarcinoma cell tumorigenicity PMID: 23301098
24. APPL1 regulates basal NF-kappaB activity by modulating the stability of NIK, which affects the activation of p65. PMID: 22685329
25. we found that NIK and the noncanonical pathway are very prevalent in Hodgkin lymphoma PMID: 22968463
26. study shows API2-MALT1 fusion oncoprotein induces proteolytic cleavage of NF-kappaB-inducing kinase (NIK); resulting deregulated NIK activity is associated with constitutive noncanonical NF-kappaB signaling, enhanced B cell adhesion and apoptosis resistance PMID: 21273489
27. a molecular basis for the recent observation of gain-of-function activity for an N-terminal deletion mutant (DeltaN324) of NIK, leading to constitutive non-canonical NF-kappaB signaling with enhanced B-cell adhesion and apoptosis resistance. PMID: 22718757
28. NIK is one of the direct target genes of miR-520e. PMID: 22105365
29. NIK mediates both beta-catenin and NF-kappaB regulated transcription to modulate melanoma survival and growth PMID: 21963849
30. Genetic lesions of the TRAF3 and MAP3K14 genes in classical Hodgkin lymphoma. PMID: 22469134
31. NIK activity in nonhematopoietic cells controls Th2 cell development and prevents eosinophil-driven inflammatory disease, most likely using a signaling pathway that operates independent of the known NIK substrate IKKalpha. PMID: 22474019
32. Cigarette smoke and TNFalpha increase NIK levels causing phosphorylation of IKKalpha, which leads to histone acetylation. PMID: 21887257
33. A role for NF-kappaB noncanonical pathway activation in modulating diabetes-induced inflammation in renal tubular epithelium. PMID: 21869881
34. Adiponectin treatment inhibited NIK-induced NF-kappaB activation and restored insulin sensitivity by restoring phosphatidylinositol 3 kinase activation and subsequent serine-threonine kinase phosphorylation. PMID: 21846802
35. findings suggest that the CC genotype of NIK rs7222094 is associated with increased mortality and organ dysfunction in septic shock patients, perhaps due to altered regulation of NF-kappaB pathway genes, including CXCL10 PMID: 21257964
36. plays a key role in constitutive NF-kappaB activation in non-small cell lung cancer cells PMID: 20338663
37. TNF-alpha and carrageenan in combination act to increase NIK phosphorylation, thereby increasing activation of the non-canonical pathway of NF-kappaB activation PMID: 20937806
38. Data suggest that NIK and genes induced by the NIK-mediated constitutive NF-kappaB activation could be therapeutic targets of basal-like breast cancer. PMID: 20735436
39. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. PMID: 20682767
40. Data show that NIK with mutations in the IKKalpha-targeted serine residues was more stable than wild-type NIK and resulted in increased noncanonical NF-kappaB signaling. PMID: 20501937
41. These results suggest that augmentation of NF-kappaB-inducing kinase, IkappaB kinase-alpha, and pH3 in response to oxidative stress is involved in cell death after cerebral ischemia (or stroke). PMID: 20125184
42. the LTbetaR modifies the ubiquitin:NIK E3 ligase, and also acts as an allosteric regulator of the ubiquitin:TRAF E3 ligase PMID: 20348096
43. Data provide analysis of the IKK/NIK inter-relationship and its impact on NF-kappaB control by mathematical modelling. PMID: 19909783
44. results demonstrate that IKK2 is essential for dendritic cell activation induced by CD40L or contact with allogeneic T cells, but not by LPS, whereas NIK is not required for any of these signals PMID: 12393548
45. induction of noncanonical NF-kappaB signaling may involve the rescue of NIK from TRAF3-mediated negative regulation PMID: 15084608
46. subcellular distribution of NIK to different compartments might be a means of regulating the function of this kinase PMID: 15252129
47. Results for the first time place NF-kappa B-inducing kinase (NIK), previously shown to function in TNF signaling, within the interferon signal transduction pathway PMID: 16009713
48. This study demonstrates that NF-kappaB-inducing kinase (NIK) is a critical target of the endogenous ROS in NF-kappaB pathways. PMID: 17729113
49. NF-kappaB-inducing kinase phosphorylates and blocks the degradation of Down syndrome candidate region 1 PMID: 18056702
50. NIK functions downstream of Cot to mediate p65 phosphorylation. PMID: 18439422

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HGNC: 6853

OMIM: 604655

KEGG: hsa:9020

UniGene: Hs.404183