Recombinant Human Neprilysin(MME),partial

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Code CSB-YP014653HU
Product Type Recombinant Protein
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Uniprot No. P08473
Relevance Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids . Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond . Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 . Involved in the degradation of atrial natriuretic factor (ANF) . Displays UV-inducible elastase activity toward skin preelastic and elastic fibers .
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP014653HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MME.
  • Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP014653HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MME.
Storage Buffer Tris-based buffer,50% glycerol
Alias AtriopeptidaseCommon acute lymphocytic leukemia antigen ;CALLAEnkephalinaseNeutral endopeptidase 24.11 ;NEP ;Neutral endopeptidase;Skin fibroblast elastase ;SFE; CD10
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence YDDGICKSSDCIKSAARLIQNMDATTEPCTDFFKYACGGWLKRNVIPETSSRYGNFDILRDELEVVLKDVLQEPKTEDIVAVQKAKALYRSCINESAIDSRGGEPLLKLLPDIYGWPVATENWEQKYGASWTAEKAIAQLNSKYGKKVLINLFVGTDDKNSVNHVIHIDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEERLPIDENQLALEMNKVMELEKEIANATAKPEDRNDPMLLYNKMTLAQIQNNFSLEINGKPFSWLNFTNEIMSTVNISITNEEDVVVYAPEYLTKLKPILTKYSARDLQNLMSWRFIMDLVSSLSRTYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKRAEEKALAIKERIGYPDDIVSNDNKLNNEYLELNYKEDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSASNFKEQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGLGQAYRAYQNYIKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFSEAFHCRKNSYMNPEKKCRVW
Research Area Cancer
Source Yeast
Gene Names MME
Protein Names Recommended name: Neprilysin EC= 3.4.24.11 Alternative name(s): Atriopeptidase Common acute lymphocytic leukemia antigen Short name= CALLA Enkephalinase Neutral endopeptidase 24.11 Short name= NEP Short name=
Expression Region 52-750aa
Tag Info N-terminal 6xHis-tagged
Mol. Weight 81.8kDa
Protein Description Partial
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids
Involvement in disease Charcot-Marie-Tooth disease 2T (CMT2T); Spinocerebellar ataxia 43 (SCA43)
Subcellular Location Cell membrane, Single-pass type II membrane protein
Protein Families Peptidase M13 family
Database Links

HGNC: 7154

OMIM: 120520

KEGG: hsa:4311

STRING: 9606.ENSP00000353679

UniGene: Hs.307734

Pathway Renin-angiotensin system
Hematopoietic cell lineage

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