The gene MME encodes for the protein membrane metallo-endopeptidase (NEP), also known as neprilysin. NEP is a transmembrane glycoprotein that plays a crucial role in the degradation of various peptide substrates, including amyloid-β in Alzheimer's disease and neuropeptides in the nervous system. It operates through a zinc-dependent mechanism, acting as a key regulator in several biological processes. Mutations in the MME gene are associated with late-onset Charcot-Marie-Tooth disease type 2 (CMT2), a peripheral neuropathy characterized by progressive muscle weakness and atrophy. Research into MME mutations has led to advancements in understanding the molecular mechanisms of CMT2 and has potential implications for drug development targeting this disease.
Recombinant Human Neprilysin (MME), partial (CSB-YP014653HU)
Validated Data
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP014653HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MME.
Based on the SEQUEST from database of Yeast host and target protein, the LC-MS/MS Analysis result of CSB-YP014653HU could indicate that this peptide derived from Yeast-expressed Homo sapiens (Human) MME.
MME Recombinant Monoclonal Antibody (CSB-RA940661A0HU)
Validated Data
Western Blot
Positive WB detected in: U251 whole cell lysate
All lanes: MME antibody at 1:1500
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 86 kDa
Observed band size: 100 kDa
The following MME reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
MME Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA014653GA01HU | MME Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA985136 | MME Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-MA000230 | MME Monoclonal Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA005556 | MME Antibody | Human,Mouse,Rat | WB, ELISA |
CSB-PA086078 | MME Antibody | Human,Mouse,Rat | ELISA,WB,IHC |
CSB-PA927708 | MME Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA897259 | MME Antibody | Human,Mouse,Rat | IHC,ELISA |
CSB-PA014653LA01HU | MME Antibody | Human | ELISA, IHC |
CSB-PA014653LB01HU | MME Antibody, HRP conjugated | Human | ELISA |
CSB-PA014653LC01HU | MME Antibody, FITC conjugated | Human | |
CSB-PA014653LD01HU | MME Antibody, Biotin conjugated | Human | ELISA |
CSB-PA014653LA11HU | MME Antibody | Human | ELISA, IHC, IF |
CSB-PA014653LB11HU | MME Antibody, HRP conjugated | Human | ELISA |
CSB-PA014653LC11HU | MME Antibody, FITC conjugated | Human | |
CSB-PA014653LD11HU | MME Antibody, Biotin conjugated | Human | ELISA |
CSB-RA940661A0HU | MME Recombinant Monoclonal Antibody | Human | ELISA, WB |
CSB-RA187479A0HU | MME Recombinant Monoclonal Antibody | Human | ELISA, IHC |
MME Proteins for Sus scrofa (Pig)
Code | Product Name | Source |
---|---|---|
CSB-YP014653PI CSB-EP014653PI CSB-BP014653PI CSB-MP014653PI CSB-EP014653PI-B |
Recombinant Pig Neprilysin (MME) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MME Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP014653HU | Recombinant Human Neprilysin (MME), partial | Yeast |
CSB-EP014653HU CSB-BP014653HU CSB-MP014653HU CSB-EP014653HU-B |
Recombinant Human Neprilysin (MME), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MME Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP362251RA CSB-EP362251RA CSB-BP362251RA CSB-MP362251RA CSB-EP362251RA-B |
Recombinant Rat Neprilysin (Mme), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MME Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP722446PYX CSB-EP722446PYX CSB-BP722446PYX CSB-MP722446PYX CSB-EP722446PYX-B |
Recombinant Pongo abelii Neprilysin (MME), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MME Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP723409MO CSB-EP723409MO CSB-BP723409MO CSB-MP723409MO CSB-EP723409MO-B |
Recombinant Mouse Neprilysin (Mme), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MME Proteins for Oryctolagus cuniculus (Rabbit)
Code | Product Name | Source |
---|---|---|
CSB-CF014653RB | Recombinant Rabbit Neprilysin (MME) | in vitro E.coli expression system |
CSB-YP014653RB1 CSB-EP014653RB1 CSB-BP014653RB1 CSB-MP014653RB1 CSB-EP014653RB1-B |
Recombinant Rabbit Neprilysin (MME), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
MME ELISA Kit for Mus musculus (Mouse)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL014653MO | Mouse Neprilysin(MME) ELISA kit | serum, plasma,tissue homogenates | 0.039 ng/mL |
MME ELISA Kit for Rattus norvegicus (Rat)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-EL014653RA | Rat Neprilysin(MME) ELISA kit | serum, plasma, tissue homogenates | 11.75 pg/mL |
MME ELISA Kit for Homo sapiens (Human)
Code | Product Name | Sample Types | Sensitivity |
---|---|---|---|
CSB-E13347h | Human Neprilysin(NEP) ELISA Kit | serum, plasma, tissue homogenates | 19.5 pg/mL |