C1QTNF12

C1QTNF12 encodes C1q and tumor necrosis factor related protein 12 (CTRP12), a member of the CTRP family. It modulates glucose and lipid metabolism by activating AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma (PPARγ) pathways, enhancing insulin sensitivity in adipose tissue and promoting lipid oxidation in the liver.
Dysregulation of CTRP12 is linked to type 2 diabetes, obesity, and metabolic syndrome—low circulating levels correlate with insulin resistance and visceral adiposity. Preclinical studies show recombinant CTRP12 improves metabolic parameters in animal models, though no clinical trials for CTRP12-targeted therapies have been initiated, marking it a promising candidate for metabolic disorder interventions.