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Recombinant Human UDP-N-acetylhexosamine pyrophosphorylase (UAP1)

Recombinant Human UDP-N-acetylhexosamine pyrophosphorylase (UAP1)

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Code	CSB-EP618067HU
Abbreviation	Recombinant Human UAP1 protein
MSDS	MSDS Datasheet
Size	$224
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details
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Target Background

Product Details

Purity

Greater than 90% as determined by SDS-PAGE.

Target Names

UAP1

Uniprot No.

Q16222

Research Area

Signal Transduction

Alternative Names

AGX 1; AGX; AGX-1; AGX-2; AGX1; Antigen X; AntigenX; SPAG 2; SPAG2; Sperm associated antigen 2; Sperm-associated antigen 2; UAP 1; uap1; UAP1_HUMAN; UDP N acetylhexosamine pyrophosphorylase; UDP N acteylglucosamine pyrophosphorylase 1; UDP-N-acetylglucosamine pyrophosphorylase

Species

Homo sapiens (Human)

Source

E.coli

Expression Region

1-522aa

Target Protein Sequence

MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSSHQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAYPKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTKHKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDMEQRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQVVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPYVDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTTARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQCEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Mol. Weight

62.8kDa

Protein Length

Full Length

Tag Info

N-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
Note: If you have any special requirement for the glycerol content, please remark when you place the order.
If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

3-7 business days

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

Our Recombinant Human UAP1 protein is carefully designed for researchers working in the field of signal transduction. This full-length UDP-N-acetylhexosamine pyrophosphorylase (Antigen X; Sperm-associated antigen 2) is expressed in an E.coli system, spanning the 1-522aa expression region to provide the complete protein sequence. The UAP1 protein is N-terminal 6xHis-tagged, which simplifies purification and detection, ensuring consistent performance and reliable results in your experiments.

With a purity greater than 90% as determined by SDS-PAGE, our Recombinant Human UAP1 protein is available in both liquid and lyophilized powder forms. Trust in this high-quality protein to support your signal transduction research and provide dependable, reproducible outcomes.

Customer Reviews and Q&A

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Target Background

Function

Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.

Gene References into Functions

Results identified an enzyme, UAP1, which is highly overexpressed in prostate cancer and protects cancer cells from endoplasmic reticulum stress conferring a growth advantage. PMID: 25241896

Subcellular Location

Cytoplasm. Note=In spermatozoa, localized to the principal piece of the tail, the neck region of the head and to a lesser extent, the midpiece of the tail.

Protein Families

UDPGP type 1 family

Tissue Specificity

Widely expressed. Isoform AGX1 is more abundant in testis than isoform AGX2, while isoform AGX2 is more abundant than isoform AGX1 in somatic tissue. Expressed at low level in placenta, muscle and liver.

Database Links

HGNC: 12457

OMIM: 602862

KEGG: hsa:6675

STRING: 9606.ENSP00000356903

UniGene: Hs.492859

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