Recombinant Mouse Fibroblast growth factor 4 (Fgf4)

1. results demonstrate the mechanism for the maintenance of the undifferentiated state of embryonic stem cells via the inhibition of the FGF4-PKCzeta-MEK-ERK1/2 pathway by O-GlcNAcylation on PKCzeta. PMID: 29249667
2. The correlation in expression of FGF4 with specific stages of tooth morphogenesis support its regulatory function. PMID: 28806497
3. We demonstrate with genetic evidence that the Wnt5a gradient acts as a global cue that is instructive in establishing planar cell polarity (PCP) in the limb mesenchyme, and that Wnt5a also plays a permissive role to allow Fgf4 and Fgf8 signaling to orient PCP. PMID: 29615464
4. the paternal genome facilitates the proliferation of trophoblast cells without FGF4 signaling PMID: 26498204
5. There was intense Fgf4 expression observed in the PEK of the cap-stage tooth germ at E14. At E15, Fgf4 became sparse in the epithelium except for the PEK. Fgf4 was exclusively expressed in the apical end of the labial epithelium during E16-18 PMID: 26042621
6. With efficient chimera-forming capability using a medium containing fibroblast growth factor (FGF)-4. PMID: 25515008
7. Taken together, our results demonstrated that mating behaviours influenced embryonic development in vitro by decreasing FGF4 expression. PMID: 23172713
8. the amount of FGF4 is limited and regulates PE/EPI proportions in the mouse embryo. PMID: 24063807
9. The role of Fgf4 in response to apoptosis and genotoxic stress is discussed. PMID: 23145002
10. FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse PMID: 23193166
11. FGF4 is required to maintain a population of progenitor cells in the epiblast that generates mesoderm and contributes to the stem cell population that is incorporated in the tailbud and required for axial elongation of the mouse embryo after gastrulation. PMID: 22954964
12. This study uncovers an important role of HDAC1 and histone modifications in the repression of Fgf4 and perhaps other pluripotency genes during embryonic stem cell differentiation. PMID: 21321941
13. study provides genetic evidence that FGFs are the wavefront signal and identifies the data show that FGF action maintains WNT signaling, and that both signaling pathways are required in parallel to maintain PSM progenitor tissue PMID: 21368122
14. Cells ceased proliferation and differentiated when FGF4, heparin, and rat embryonic fibroblasts conditioned medium were removed. PMID: 21215265
15. KDM7A is a dual-specificity histone demethylase that regulates neural differentiation through FGF4. PMID: 20084082
16. FGF4 and FGF8 regulate cell number in the nascent limb bud and are required for survival of cells located far from the AER PMID: 12152071
17. p300 associates physically with and can mediate the action of the distal enhancer of the FGF-4 gene PMID: 12488456
18. Fgf4 is expressed in early inner ear development. PMID: 14517998
19. The blues transcription factor binds the enhancer of Fgf4 and represses transcription. PMID: 14988001
20. Shh-expressing cells and their descendants cannot express Gremlin; proliferation of these descendants forms a barrier separating the Shh signal from Gremlin-expressing cells which breaks down the Shh-Fgf4 loop and affects limb size PMID: 15256670
21. By creating mice lacking both Fgf4 and Fgf8 function in the forelimb apical ectodermal ridge, we show that limb bud mesenchyme fails to survive in the absence of both FGF family members. PMID: 15328019
22. FGF4 signaling in trophoblast stem cells selectively inhibits the ability of TGF-beta to repress c-myc expression. PMID: 15464579
23. Fgf4 expression is induced by the transforming growth factor beta-related protein Nodal. PMID: 15505202
24. NF-Y can stimulate or repress the FGF-4 promoter in an enhancer-dependent manner PMID: 16128003
25. Increasing Fgf4 expression in the mouse limb bud causes polysyndactyly and rescues the skeletal defects that result from loss of Fgf8 function. PMID: 16308330
26. suggests that the differences seen in FGF-4 enhancer activity may reflect a mechanism used to decrease, but not abolish, FGF-4 expression as the early embryo develops. PMID: 16523502
27. In the embryonic and in the postnatal brain FGF-4 has an ability to promote neural stem cell proliferation and neuronal differentiation. PMID: 16723380
28. Fgf4 stimulation of Erk1/2 is an autoinductive stimulus for naive ES cells to exit the self-renewal programme. PMID: 17660198
29. analysis of compound mouse mutants defective in genes comprising the Fgf/Shh positive loop provided genetic evidence that FGF signalling can repress Grem1 expression, revealing a novel Fgf/Grem1 inhibitory loop PMID: 18594511
30. involved in early anterior mesendoderm differentiation PMID: 18940732
31. Fgf4 positively regulated Pea3, Sprouty1, and 2 expression in chick limb mesenchyme. PMID: 19384958
32. PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation PMID: 19531481

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KEGG: mmu:14175

STRING: 10090.ENSMUSP00000056752

UniGene: Mm.4956