Recombinant Mouse Myc proto-oncogene protein (Myc)

1. These findings established a link between GCN5 and the FGF signaling pathway and highlighted specific GCN5-MYC partnerships in gene regulation during early differentiation. PMID: 29249668
2. amino acid-controlled cMyc has an essential role in NK cell metabolism and function PMID: 29904050
3. Kidney specific MYC activation results in papillary clear cell renal cell carcinoma. PMID: 28593993
4. c-Myc is essential for tumor initiation, maintenance, and metastasis. PMID: 29440228
5. Genomic characterization of Emu-Myc mouse lymphomas identifies Bcor as a Myc cooperative tumor-suppressor gene. PMID: 28262675
6. The data supports an indispensable role for Mule in cardiac homeostasis through the regulation of mitochondrial function via maintenance of Pgc-1alpha and Pink1 expression and persistent negative regulation of c-Myc. PMID: 28148912
7. MYC binding is enriched at neuroendocrine genes in tumor cells and loss of MYC reduces ductal-neuroendocrine lineage heterogeneity, while deregulated MYC expression in KRAS mutants increases this phenotype. PMID: 29170413
8. Although either BCR or CD40 ligation induced c-Myc in naive B cells, both signals were required to highly induce c-Myc, a critical mediator of GC B cell survival and cell cycle reentry. PMID: 29396161
9. Myc is a component that links neuromesodermal progenitors maintenance and pre-somitic mesoderm maturation during the body axis elongation stages of mouse embryogenesis. PMID: 30061166
10. Myc potentiates the Wnt/beta-catenin signalling pathway, which cooperates with the transcriptional regulatory network in sustaining embryonic stem cell self-renewal. PMID: 27301576
11. clusters of enhancers, such as BENC in the myc gene, form highly combinatorial systems that allow precise control of gene expression across normal cellular hierarchies and which also can be hijacked in malignancies PMID: 29342133
12. Conditional deletion of Myc in hyaloid vascular endothelial cells suppressed both proliferation and cell death. PMID: 29777010
13. c-Myc repression during development is crucial for the maturation of preacinar cells, and c-Myc overexpression can contribute to pancreatic carcinogenesis through the induction of a dedifferentiated state. PMID: 28159836
14. MYC negatively regulated the expression of genes involved in mitochondrial biogenesis and maintenance but positively regulated genes involved in DNA and histone methylation. Knockdown of MYC in colorectal cancer cells reset the altered metabolism and suppressed cell growth. PMID: 28847964
15. High myc expression is associated with Intestinal Tumorigenesis. PMID: 29533773
16. results shed light on how overexpressed MYC alters the various phases of the RNAPII cycle and the resulting transcriptional response. PMID: 28904013
17. c-Myc overexpression stimulated proliferation and activation of renal fibroblasts by inducing integrin alphav-mediated TGF-beta signaling. PMID: 28483378
18. In the Myc-induced liver tumor model in zebrafish, a dramatic increase of liver size with neoplastic features was observed, as well as enhanced angiogenesis, and increase liver-infiltrated neutrophils and hypoxia. This model provides an excellent platform for study of tumor microenvironment. PMID: 27549025
19. Using inducible genetic mosaics, we overexpressed Myc in the epicardium and determined the differential expansion of Myc-overexpressing cells with respect to their wild type counterparts. Myc-overexpressing cells overcolonized all epicardial-derived lineages and showed increased ability to invade the myocardium and populate the vasculature. PMID: 27752085
20. Nac1 overexpression promotes ESC proliferation and delays ESC differentiation in the absence of leukemia inhibitory factor (LIF). Furthermore, we demonstrated that Nac1 directly binds to the c-Myc promoter and regulates c-Myc transcription. PMID: 28548937
21. this study demonstrates that miR-451 regulates T cell proliferative responses in part via a Myc-dependent mechanism PMID: 28378118
22. AKAP1 is a transcriptional target of Myc, and it supports mTOR pathway and the growth of cancer cells. PMID: 28569781
23. High c-myc expression is associated with gliomagenesis. PMID: 26993778
24. the role of phosphorylation on AID serine38 in AID activity at the Immunoglobulin switch region and off-target Myc gene, is reported. PMID: 29122947
25. This study demonstrates that LMP2A uses the role of MYC in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo. PMID: 29074502
26. Results show Myc to be dispensable for sustained in vivo hepatocyte proliferation but necessary for maintaining normal lipid homeostasis. PMID: 27105497
27. Pin1 silencing in lymphomas retarded disease progression in mice, making Pin1 an attractive therapeutic target in Myc-driven tumors. PMID: 26943576
28. beta-catenin cooperates with the transcription factor Myc to activate the progenitor renewal program. PMID: 28993399
29. Gfi1 disruption antagonized the tumor-promoting effects of Ezh2 loss; conversely, Gfi1 overexpression collaborated with Myc to bypass effects of Trp53 inactivation in driving medulloblastoma progression in primary cerebellar neuronal progenitors. PMID: 28329683
30. rather than via E-Box binding, cMyc acts in the dorsal neural tube by interacting with another transcription factor, Miz1, to promote self-renewal. The finding that cMyc operates in a non-canonical manner in the premigratory neural crest highlights the importance of examining its role at specific time points and in an in vivo context. PMID: 27926868
31. miR-17-92-dependent tuning of LKB1 levels regulates both the metabolic potential of Myc+ lymphomas and tumor growth in vivo. PMID: 27498867
32. Under diabetic oxidative stress or H2O2 stimulation, nuclear beta-catenin accumulation upregulated downstream c-Myc and further facilitated DNA damage and p53-mediated apoptosis as well as cell viability reduction, followed by phenotypic changes of cardiac dysfunction, interstitial fibrosis deposition and myocardial atrophy. PMID: 28989026
33. B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3beta inhibition PMID: 28562582
34. High Myc expression is associated with hepatocarcinogenesis. PMID: 28481866
35. Myc-high embryonic stem cells (ESCs) approach the naive pluripotency state, whereas Myc-low ESCs are closer to the differentiation-primed state. PMID: 28919206
36. Authors here report the first MBG3 model from embryonic cerebellar cells by Myc activation and loss of Trp53 function using in utero electroporation (EP)-based in vivo gene transfer combined to a Cre/LoxP-mediated technology. PMID: 28504719
37. by controlling both nanodomain decompaction and PolII promoter escape Myc stands as a master regulator of transcriptome amplification during B cell activation. PMID: 28803781
38. these results indicate that PIAS1 is a positive regulator of MYC. PMID: 27239040
39. this study shows that that deletion of Sox2 increases the frequency of IgH:c-Myc translocations PMID: 28188246
40. findings highlight a MYC/ERRalpha pathway that contributes to physiological and pathological bone loss by integrating the MYC/ERRalpha axis to drive metabolic reprogramming during osteoclast differentiation PMID: 28530645
41. Data show that Emu-Myc mice lacking both p21 and PUMA developed lymphoma at a rate considerably longer latency than Emu-Myc;p53(+/-)mice. PMID: 26640149
42. CRY2 and FBXL3 cooperatively degrade c-MYC preventing the development of cancer. PMID: 27840026
43. Data, including data from studies in cells from knockout mice, suggest that Prmt1 activity was necessary for c-Myc binding to acetyltransferase p300 in myeloid cells; Prmt1 inhibition decreases p300 recruitment to c-Myc target promoters and increased Hdac1 recruitment. [Prmt1, protein arginine N-methyltransferase 1; c-Myc = Proto-Oncogene Proteins c-myc; Hdac1 = histone deacetylase 1] PMID: 28652407
44. MYC-dependent attenuation of GCLC by miR-18a contributes to GSH depletion in vivo, and low GSH corresponds with increased sensitivity to oxidative stress in tumors. PMID: 28219903
45. MYC mediates cell cycle re-entry of Trp53-altered hepatocytes via AURKA binding. PMID: 27213815
46. Myc can substitute for Notch1 in leukemogenesis PMID: 27670423
47. our results show how MYC drives the production of specific eicosanoids critical for lung cancer cell survival and proliferation PMID: 27335109
48. Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc and low Bmf expression PMID: 27899442
49. Data (including data from studies using transgenic mice) suggest that expression of c-Myc in liver can be correlated with progression, regression, and recurrence of hepatocellular carcinoma (using a specific mouse model). PMID: 28432125
50. TCF7L2 mediates canonic Wnt/beta-catenin signaling and c-Myc upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt/beta-catenin to c-Myc axis can be explored for preventing and treating heart failure. PMID: 27301468

Show More

Hide All

KEGG: mmu:17869

STRING: 10090.ENSMUSP00000022971

UniGene: Mm.2444