Recombinant Mouse Nuclear factor of activated T-cells, cytoplasmic 2 (Nfatc2), partial

1. NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or deletion of NFATc2 was sufficient to attenuate the ability of the microglia to secrete cytokines. AbetaPP/PS1 (Alzheimer's disease model) x NFATc2-/- mice had attenuated cytokine levels compared to AbetaPP/PS1 mice as well as reduced microgliosis and astrogliosis with no effect on plaque load. PMID: 28505967
2. data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance. PMID: 28972088
3. These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4(+) T cell exhaustion. PMID: 28630062
4. These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies. PMID: 27399331
5. our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4(+)/CD8(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation. PMID: 26777750
6. It is a non-Hsp gene, which is essential for HSF1-mediated maintenance of whole body homeostasis PMID: 26251235
7. NFAT directs signaling enzymes to gene promoters in islets. PMID: 25496032
8. FOXP3 can inhibit NFAT driven expression of CD40L and IL-17 in CD4 T cells through its interaction with NFAT1 and inhibition of this interaction by a short synthetic peptide can modulate effector T cell activity PMID: 26324768
9. Nfatc2 and Tob1 have non-overlapping function in T cell negative regulation and tumorigenesis. PMID: 24945807
10. our findings reveal a new signaling pathway in microglia that couples TLR4 activation with the translocation of NFAT1 into mitochondria to control the microglial activation during brain infection. PMID: 26224862
11. Nfatc2 activation in osteoblasts inhibits bone formation and causes cancellous bone osteopenia. PMID: 25573264
12. our results place NFAT-dependent mechanisms as general regulators of T-cell tolerance and show that Treg-mediated suppression of T-helper cells results from the activation of NFAT-regulated gene expression. PMID: 25074018
13. NFAT promotes T cell anergy and exhaustion by binding at sites that do not require cooperation with AP-1. PMID: 25680272
14. the NFAT1 transcription factor regulates specific functions in dendritic cells that are involved in CD4 differentiation PMID: 24894426
15. The anergic state of 125Tg B cells is relieved in 125Tg/B6/NFATc2(-/-) B cells. PMID: 24507801
16. in vivo biochemical or genetic inhibition of NFATc2 activity in megakaryocyte diminishes platelet CD40L implicates the NFATc2/EGR-1 axis as a key regulatory pathway of inflammatory and immunomodulatory activity in platelets PMID: 24106272
17. NFAT1 and all-trans retinoic acid signalling pathways synergize in control of proliferation and differentiation of BM2 monoblasts. PMID: 23571271
18. NFAT1 protein activation can shift oncogenic Ras/Raf/MEK/ERK signaling to acting as a tumor suppressor pathway. PMID: 23583303
19. The translocation of NFATc2 is one of the key mechanisms by which CGRP affects T helper(Th) 9 cell differentiation and type I hypersensitivity. PMID: 23509367
20. NFAT1 C-terminal domains are necessary but not sufficient for inducing cell death. PMID: 23110116
21. The closely related transcription factors NFAT1 and NFAT4 possess distinct nuclear localization dynamics in response to cell stimulation. PMID: 23219532
22. Notch stabilizes Nfatc2 transcripts, NFATc2 suppresses Notch signaling, and both proteins inhibit osteoblast function PMID: 23166323
23. Human VRK2 is an active kinase playing a role in regulation of cancer cell invasion through the NFAT pathway and COX-2 expression. PMID: 23105117
24. These investigations illustrated the dependence of tumor-induced CD4+ T-cell anergy on NFAT1 PMID: 22865456
25. our findings highlight a pivotal role for NFATc2 in the establishment of inflammation-associated colorectal tumors mediated by control of IL-6 expression. PMID: 22738913
26. Data suggest that functional cooperation of NFAT1 and NF-kappaB (p65) synergistically enhances IL-9 transcription in CD4(+) T cells. PMID: 22427656
27. Describes a novel mechanism for NFATc2-mediated gene regulation and identifies a functional link among its repressor activity, the silencing of the suppressor pathway p15(INK4b), and its pancreatic cancer growth regulatory functions. PMID: 22079596
28. NFATc2 may play a role in the maintenance of steady-state hematopoiesis and bone remodeling in adult organisms. PMID: 21750088
29. Nfat1 is an essential transcriptional regulator of chondrocyte homeostasis in adult articular cartilage. PMID: 21452283
30. Nfatc2 likely plays an important role in Nell-1-mediated osteochondral differentiation in vitro and in vivo. PMID: 21611965
31. These results suggest an important role for NFAT1 in radio-resistant tumor-associated parenchyma PMID: 21225259
32. Nuclear Factor of Activated T-cels negatively regulates tumor necrosis factor receptor related 2 expression in activated T cells PMID: 20948279
33. Functional cooperation between transcription factor NFATc2 and the retinoic acid receptor (RAR)/retinoid X receptor (RXR) complex on the promoter region is essential for transcriptional expression of CC chemokine receptor Ccr9 gene. PMID: 21148038
34. Data show that NFATc2 inhibits polyQ aggregation in cells and is required for HSF1-mediated suppression of aggregation, and that HSF1 and NFATc2 cooperatively induce expression of PDZK3 and alphaB-crystallin, which facilitate degradation of polyQ. PMID: 20834230
35. NFAT1 hyperactivation paradoxically leads to decreased susceptibility to experimental autoimmune encephalomyelitis, supporting previous observations linking defects in Ca(2+)/NFAT signaling to lymphoproliferation and autoimmune disease. PMID: 20696888
36. the the calcineurin/NFAT pathway has a role in lymphoma/leukemogenesis [review] PMID: 20093726
37. BAI2 is a functional GPCR regulated by proteolytic processing and activates the NFAT pathway PMID: 20367554
38. CCAAT/enhancer binding protein beta (C/EBPbeta) cooperates with NFAT to control expression of the calcineurin regulatory protein RCAN1-4 PMID: 20371871
39. TRPC channels are necessary mediators of pathologic cardiac hypertrophy, in part through a calcineurin-NFAT signaling pathway PMID: 20351294
40. Data demonstrate that NFAT1 mediates PlGF-induced myelomonocytic cell recruitment via the induction of TNF-alpha. PMID: 20097868
41. High levels of NFATp activity are induced by strong TCR signals in naive CD4+ T cells and correlate with robust Th1 cell differentiation and inhibition of IL-4 transcription. PMID: 11937535
42. induce and maintain transcription of IL-4 PMID: 12355451
43. NFATC2 regulates cell cycle progression during lymphocyte activation: evidence of its involvement in the control of cyclin gene expression. PMID: 12368232
44. calcineurin/NFAT pathway negatively regulates the expression of cyclin-dependent kinase 4 (CDK4) PMID: 12453415
45. These data provide the first evidence that calcineurin is functionally active in follicular keratinocytes and that inhibition of the calcineurin-NFAT1 pathway in these cells in vivo by cyclosporin A enhances hair growth. PMID: 12734112
46. The -508 binding site of NF-AT is functionally critical in mediating NF-ATc2-induced trans-activation of the proximal promoter of transcriptional repressor of GATA (ROG), which is a direct downstream target of NF-ATc2. PMID: 14688323
47. transcriptional induction of Nfatc1 is a major function of c-Fos in osteoclast differentiation PMID: 15073183
48. sumoylation has a dual role in the nuclear localization and transcriptional activation of NFAT1 PMID: 15117942
49. identify a conserved docking site for casein kinase 1 (CK1) in NFAT proteins and show that mutation of this site disrupts NFAT1-CK1 interaction and causes constitutive nuclear localization of NFAT1 PMID: 15121840
50. Data show that the proximal promoter of IL-21 controls its Th-cell-subset-specific expression through the action of NFATc2 and T-bet. PMID: 15684054

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KEGG: mmu:18019

STRING: 10090.ENSMUSP00000074198

UniGene: Mm.116802