Recombinant Mouse Proto-oncogene Wnt-1 (Wnt1)

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Code CSB-EP026128MO
Size $388
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  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Greater than 85% as determined by SDS-PAGE.
Target Names
Uniprot No.
Research Area
Stem Cells
Alternative Names
Proto-oncogene Int-1
Mus musculus (Mouse)
Expression Region
Target Protein Sequence
Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
Mol. Weight
45.8 kDa
Protein Length
Full Length of Mature Protein
Tag Info
N-terminal 10xHis-tagged and C-terminal Myc-tagged
Liquid or Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
3-7 business days
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA
Please contact us to get it.

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Target Background

Ligand for members of the frizzled family of seven transmembrane receptors. Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling. Plays an essential role in the development of the embryonic brain and central nervous system (CNS). Has a role in osteoblast function, bone development and bone homeostasis.
Gene References into Functions
  1. aberrant expression of AF1q may activate Wnt/beta-catenin signaling and result in podocyte injury. PMID: 29069662
  2. Wnt1a maintains characteristics of dermal papilla cells that induce mouse hair regeneration in a 3D preculture system PMID: 26118627
  3. These data suggested that Wnt/beta-catenin pathway might be a potential target to treat the LPS-induced inflammation in ALI. PMID: 29246763
  4. Wnt signaling regulates airway epithelial stem cells in adult murine submucosal glands. PMID: 27341073
  5. Pax9-dependent Wnt signaling has a role in palatogenesis and cleft palates PMID: 28893947
  6. Data show that autocrine Wnt secretion is important for the survival, chromosomal stability, differentiation, and tumorigenic potential of embryonic stem cells (ESCs). PMID: 28074006
  7. Results demonstrated functional differences in the molecular mechanisms downstream of Wnt1 function in the diencephalon, in relation to the spinal cord. Wnt1 signal determines the patterning of the diencephalic dorso-ventral axis PMID: 26452989
  8. Data show that both transgenic Wnt1-cre and P0-cre are similarly effective in deleting beta-catenin in the neural crest. PMID: 27184910
  9. data suggest that WNT1-related osteogenesis imperfecta and osteoporosis are caused in part by decreased mTORC1-dependent osteoblast function resulting from loss of WNT1 signaling in osteocytes. PMID: 28628032
  10. Administration of EET alters Wnt1, NOV, and HO-1 signaling to prevent obesity-induced cardiomyopathy in obese mice. PMID: 28576832
  11. Data indicate that Wnt1 proto-oncogene protein (WNT1) is the direct target of microRNA miR-34a in dendritic cell (DC). PMID: 28199987
  12. The data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages. PMID: 27001213
  13. High WNT1 promoted stem-ness characteristics and metastasis potential in sphere-forming liver cancer stem cells. PMID: 26735577
  14. Decreased expressions of Wnt1 and Wnt5a. PMID: 26537990
  15. we provide unequivocal evidence that epithelial-derived Wnt1 is sufficient to drive interstitial fibrosis in the absence of any injury. PMID: 26204899
  16. Data show that elongator protein 3 (Elp3) trigger Wnt-driven tumor initiation in the intestine, and Elp3 deficiency strongly impaired radiation-induced intestinal regeneration. PMID: 26527802
  17. Fasudil prevents loss of dopamine neurons in the MPTP mice model of PD through inflammatory inhibition via activation of PI3K/p-Akt and WNT1/Fzd1/beta-catenin cell signaling pathways. PMID: 26045742
  18. Wnt has a role in striatal synaptic degeneration and impaired motor behavior in adult mice PMID: 25318560
  19. Agonists of epoxyeicosatrienoic acids reduce infarct size and ameliorate cardiac dysfunction via activation of HO-1 and Wnt1 canonical pathway. PMID: 25677507
  20. this study gives new insights into transcriptional regulating mechanisms of Wnt-mediated Isl1 expression during cardiomyocyte differentiation. PMID: 24610003
  21. Data show that bone marrow mesenchymal stem cell (BM-MSC)-generated Wnt1a promotes the dermal papilla's ability to induce hair cycling and regeneration. PMID: 24961246
  22. modulates neuronal function, hippocampal neurogenesis, and synaptic plasticity and that downregulation of Wnt signaling could be involved in the cognitive decline associated with aging and also with the physiopathology of Alzheimer's disease (AD). PMID: 25443287
  23. BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity PMID: 25483966
  24. in the absence of retinoid signaling via RARbeta, reduced IGF-1 signaling results in suppression of epithelial-mesenchymal transition and delays tumorigenesis induced by the Wnt1 oncogene PMID: 25422594
  25. results revealed that in Wnt-driven tumors, an attenuation of IGF1R signaling accelerates tumorigenesis and promotes more aggressive phenotypes with potential implications for understanding TNBC pathobiology and treatment PMID: 25092896
  26. The swaying mouse is a model of osteogenesis imperfecta caused by WNT1 mutations. PMID: 24634143
  27. Results indicate an important role for the canonical Wnt/beta-catenin pathway in the dendritic cells (DCs)-mediated regulation of allergic responses in the lung. PMID: 24929002
  28. a broader role for Wnt/beta-catenin signaling in contributing to progenitor cell proliferation in nonhairy epithelia and interfollicular epidermis under homeostasis, is reported. PMID: 24315444
  29. Wnt activation, rather than mature hair follicles, is required for adipocyte generation in murine epidermis. PMID: 24706781
  30. Concomitant expression of Wnt1 and KRASG12D in pancreatic epithelium stimulates development of mucinous cystic neoplasm (MCN)-like lesions in female mice. PMID: 24067880
  31. The results indicate the involvement of Wnt1 and Fzd1 in the pathogenesis and development of amyotrophic lateral sclerosis. PMID: 23553522
  32. Marked elevation of Wnt1 expression in the ventral midbrain is correlated with disruption of the differentiation program of ventral dopaminergic neurons. PMID: 23648512
  33. WNT signaling, which is important in developmental processes of the nervous system, plays a critical role in neuropathic pain after sciatic nerve injury and bone cancer in rodents PMID: 23585476
  34. Lgr4 is critically involved in the maintenance of intestinal homeostasis and protection against inflammatory bowel disease through modulation of the Wnt/beta-catenin signaling pathway PMID: 23393138
  35. Axin2-positive tympanic border cells are Wnt responsive and can act as precursors to sensory epithelial cells in the postnatal cochlea. PMID: 23444352
  36. The spatial and temporal function of Wnt1 in midbrain and cerebellum patterning and in midbrain dopamine neuron development in vivo. PMID: 23444360
  37. Wnt1 and Wnt5a interact genetically and cooperate to promote midbrain DA neuron development in vivo. PMID: 23324743
  38. Matrix rigidity activates Wnt signaling through down-regulation of Dickkopf-1 protein PMID: 23152495
  39. cyclin-dependent kinase 2-associated protein 1 (CDK2AP1), an essential gene for early embryonic development, plays a role in pluripotency of ESC by engaging MBD3 to the promoter region of Wnt signaling genes PMID: 23074223
  40. Wnt1cre/Dicer mice fail to develop neural crest-derived cartilages, therefore, have no middle ear ossicles. PMID: 22778034
  41. Low-dose radiation stimulates neural stem cell proliferation, neurogenesis in the hippocampus, and animal learning, by triggering Wnt/beta-catenin signaling cascades. PMID: 22272614
  42. these results suggest that Wnt1 could enhance tumorigenesis by conferring stem cell properties on breast cancer cells PMID: 22846569
  43. Wnt1 is anti-lymphangiogenic by suppressing melanoma-derived VEGF-C expression. PMID: 22572818
  44. The balancing act between cell proliferation and mucus production to restore barrier integrity seems to depend upon the interplay between the Wnt/beta-catenin and Notch pathways in the transmissible murine colonic hyperplasia model. PMID: 22710872
  45. Dickkopf2 is a Wnt antagonist involved in regulation of glucose metabolism PMID: 22733757
  46. GSK3beta plays an essential role in Ras degradation and inhibition of this degradation pathway by aberrant Wnt/beta-catenin signaling may contribute to Ras-induced transformation in colorectal tumorigenesis PMID: 22494971
  47. Wnt1 expression is related to molecular identity and cell migration in cerebellum development in mice. PMID: 22173107
  48. dermal Wnt signaling/beta-catenin has roles in fibroblast proliferation and in the epidermal hair follicle initiation program PMID: 22434869
  49. lipid modification of Wnt1 is required for Wnt secretion, but not stability PMID: 22046319
  50. Acute ischaemic cardiac injury upregulates Wnt1 in the epicardium & later by fibroblasts in the region of injury. Wnt1 induces them to proliferate & express pro-fibrotic genes. PMID: 22085926

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Subcellular Location
Secreted, extracellular space, extracellular matrix. Secreted.
Protein Families
Wnt family
Tissue Specificity
Testis and mid-gestational embryos. In the testis, detected only in postmeiotic germ cells undergoing differentiation from round spermatids into mature spermatozoa. In the embryos, expression is restricted to the developing CNS in regions of the neural tu
Database Links
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