Product Type | Recombinant Protein |
Uniprot No. | Q5IS54 |
Abbreviation | CASP3 |
Species | Pan troglodytes (Chimpanzee) |
Gene Names | CASP3 |
Protein Names | Recommended name: Caspase-3 Short name= CASP-3 EC= 3.4.22.56 Cleaved into the following 2 chains: 1. Caspase-3 subunit p17 2. Caspase-3 subunit p12 |
Storage | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C. |
Notes | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Function | Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). |
Subcellular Location | Cytoplasm |
Protein Families | Peptidase C14A family |
Database Links |
KEGG: ptr:461669 STRING: 9598.ENSPTRP00000054330 UniGene: Ptr.3233 |
Pathway |
MAPK signaling pathway
p53 signaling pathway TNF signaling pathway Apoptosis IL-17 signaling pathway Natural killer cell mediated cytotoxicity AGE-RAGE signaling pathway in diabetic complications ER Stress pathway |
Product Name | Recombinant Pan troglodytes Caspase-3(CASP3),Yeast |
Code | CSB-YP705445EQV |
Size | Pls inquiry other sizes |
Source | Yeast |
Purity | >85% (SDS-PAGE) |
Tag Info | The following tags are available. N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
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Sequence | SG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETD |
Expression Region | 29-175 |
Protein Description | Full Length of Mature Protein |
Storage Buffer | Tris-based buffer,50% glycerol |
Still Have Questions? | Leave a Message or Start an on-line Chat |
Product Name | Recombinant Pan troglodytes Caspase-3(CASP3),E.coli |
Code | CSB-EP705445EQV |
Size | Pls inquiry other sizes |
Source | E.coli |
Purity | >85% (SDS-PAGE) |
Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-SUMO-tagged and C-terminal Myc-tagged N-terminal His-B2M-tagged and C-terminal Myc-tagged N-terminal His-GST-tagged and C-terminal Myc-tagged N-terminal His-tagged N-terminal His-SUMO-tagged N-terminal His-B2M-tagged N-terminal His-GST-tagged N-terminal GST-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
Sequence | SG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETD |
Expression Region | 29-175 |
Protein Description | Full Length of Mature Protein |
Storage Buffer | Tris-based buffer,50% glycerol |
Still Have Questions? | Leave a Message or Start an on-line Chat |
Product Name | Recombinant Pan troglodytes Caspase-3(CASP3),Baculovirus |
Code | CSB-BP705445EQV |
Size | Pls inquiry other sizes |
Source | Baculovirus |
Purity | >85% (SDS-PAGE) |
Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
Sequence | SG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETD |
Expression Region | 29-175 |
Protein Description | Full Length of Mature Protein |
Storage Buffer | Tris-based buffer,50% glycerol |
Still Have Questions? | Leave a Message or Start an on-line Chat |
Product Name | Recombinant Pan troglodytes Caspase-3(CASP3),Mammalian cell |
Code | CSB-MP705445EQV |
Size | Pls inquiry other sizes |
Source | Mammalian cell |
Purity | >85% (SDS-PAGE) |
Tag Info | The following tags are available. N-terminal His-tagged and C-terminal Myc-tagged N-terminal His-tagged Tag-Free The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
|
Sequence | SG ISLDNSYKMD YPEMGLCIII NNKNFHKSTG MTSRSGTDVD AANLRETFRN LKYEVRNKND LTREEIVELM RDVSKEDHSK RSSFVCVLLS HGEEGIIFGT NGPVDLKKIT NFFRGDRCRS LTGKPKLFII QACRGTELDC GIETD |
Expression Region | 29-175 |
Protein Description | Full Length of Mature Protein |
Storage Buffer | Tris-based buffer,50% glycerol |
Still Have Questions? | Leave a Message or Start an on-line Chat |
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