Recombinant Rabbit Metalloproteinase inhibitor 1(TIMP1)

Code CSB-YP023560RB
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Source Yeast
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Code CSB-EP023560RB
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Source E.coli
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Code CSB-EP023560RB-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP023560RB
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Source Baculovirus
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Code CSB-MP023560RB
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names TIMP1
Uniprot No. P20614
Alternative Names TIMP1; Metalloproteinase inhibitor 1; Tissue inhibitor of metalloproteinases 1; TIMP-1
Species Oryctolagus cuniculus (Rabbit)
Expression Region 24-207
Target Protein Sequence CTCVPPH PQTAFCNSDL VIRAKFVGAP EVNHTTLYQR YEIKTTKMFK GFDALGHATD IRFVYTPAME SVCGYSHKSQ NRSEEFLIAG QLRNGLLHIT TCSFVVPWNS LSFSQRSGFT KTYAAGCDMC TVFACASIPC HLESDTHCLW TDQLLLGSDK GFQSRHLACL PQEPGLCAWQ SLRPRKD
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity).
Gene References into Functions
  1. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2, MMP-9 and TIMP-1 in rabbits with acute paraquat poisoning. PMID: 22801080
Subcellular Location Secreted
Protein Families Protease inhibitor I35 (TIMP) family
Database Links

KEGG: ocu:100009047

STRING: 9986.ENSOCUP00000009228

UniGene: Ocu.178

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