Recombinant Rat Arachidonate 5-lipoxygenase (Alox5)

1. 5-LOX plays an important role in activating apoptosis and repressing neutrophils activation during acute necrotizing pancreatitis. PMID: 29421656
2. Our results indicate that 5-lipoxygenase activation is mechanistically involved in chronic hepatic injury in a rat model of chronic aluminum overload exposure and that the 5-LO signaling pathway, which associated with inflammation and oxidative stress, is a potential therapeutic target for chronic non-infection liver diseases PMID: 27368151
3. Results support 5-lipoxygenase involvement in the effect of glutoxim and molixan on intracellular Ca(2+) concentration in macrophages and indicate the inadvisability of a combined use of drugs glutoxim and molixan and antiasthmatic agent zileuton PMID: 27599517
4. 12/15-LO-derived oxidized lipids regulate histone modifications associated with profibrotic gene expression in MCs, and 12/15-LO can mediate similar actions of TGF-beta1 and diabetes. PMID: 26492974
5. Alox5 affects the osteogenic and adipogenic abilities of iPSCs in vivo and the effect of Cox2 inhibition in this system. PMID: 24906289
6. 5-Lipoxygenase and 5-LO activating protein (FLAP) colocalize in the interstitium of the renal medulla following trauma and hemorrhagic shock.. PMID: 24747451
7. Urotensin II increased aortic adventitial fibroblast expression of the 5-LO mRNA/protein by NF-kappaB activation through p38 MAPK and ERK pathways. PMID: 23053343
8. 5-lipoxygenase expression can be considered as a critical event in controlling the process of mammary tumor development. PMID: 22213124
9. Cochinchina momordica seed extracts exerted significantly protective effect against cysteamine-induced duodenal ulcer by 5-lipoxygenase inhibition. PMID: 22486866
10. Zileuton can reduce rotenone-induced 5-LOX activation and cell injury in PC12 cells. PMID: 21488210
11. Cochinchina momordica seed extract is a gastroprotective agent against acute gastric mucosal damage by suppressing proinflammatory cytokines, downregulating cPLA(2), 5-LOX, and increasing the synthesis of mucus. PMID: 19130224
12. Our results confirm the key role of both COX-2 and 5-LOX in the inflammatory response to acute pancreatitis. PMID: 20977452
13. ALOX5 gene silencing decreases the frequency of necrotic cell death after anoxia-reoxygenation of cultured cardiomyocytes as well as reduces heart infarct area size at ischemia-reperfusion in vivo. PMID: 20011686
14. prolonged LPS treatment modifies activity in alveolar macrophages PMID: 12385890
15. hyperoxia increases LTB(4) output, as well as protein levels of 5-LO and FLAP, in newborn rat lungs during early postnatal life. PMID: 12490039
16. Enzyme is down-regulated and leukotriene production reduced by prolonged exposure to lipopolysaccharide. PMID: 12664571
17. Role of 5-Lipoxygenase in angiotensin II-induced NAD(P)H-oxidase activation. PMID: 12914802
18. Plays critical role in progression of pulmonary hypertension. Detrimental effect of 5-lipoxygenase is manifest only in setting of pulmonary vascular endothelial cell dysfunction. PMID: 14726295
19. arachidonic acid metabolism through LOX activity, is a major source of extracellular O(2)(*-) release in skeletal muscle. PMID: 15107407
20. iNOS regulates alveolar macrophage 5-lipoxygenase metabolism following endotoxin exposure. PMID: 15371096
21. 5-lipoxygenase nuclear import is regulated by multiple nuclear localization sequences PMID: 15479450
22. Basal iPLA2 activity, through the generation of 5-LO metabolites, regulates AMPA receptor phosphorylation of GluR1 subunits, an effect that might selectively influence the number of membrane receptors in area CA1 of the hippocampus. PMID: 15630695
23. Activation of the 5-lipoxygenase pathway previously reported in streptozotocin-induced diabetic rats could be explained by an augmented sensitivity to cysteinyl leukotrienes of the diabetic aorta. PMID: 15789618
24. Our results suggest that Nordy was capable of reducing the level of malignancy of glioma cells. PMID: 16516855
25. From these results, we conclude that OGD can activate 5-LOX in primary rat cortical neurons, and that this activation may be partly mediated via activating NMDA receptor. PMID: 16606359
26. Data show that the rat air pouch model is a reliable and useful tool for evaluating in vivo efficacy of 5-LOX inhibitors. PMID: 18295198
27. atorvastatin and pioglitazone induced an interaction between 5LO and COX2 in the cytosolic fraction of myocardial cells PMID: 18714024
28. nuclear import, which is regulated by phosphorylation on Ser-523, to determine the subcellular distribution of 5-LO, which in turn regulates leukotriene biosynthesis. PMID: 18978352
29. Lysophosphatidylcholine caused the enhancement of oxidative stress in aged aorta through reactive species generation by an activated 5-lipoxygenase pathway. PMID: 19226207

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KEGG: rno:25290

STRING: 10116.ENSRNOP00000017633

UniGene: Rn.9662