Recombinant Rat Guanine nucleotide-binding protein G (s) subunit alpha isoforms short

1. Our data revealed a positive correlation between hepatic Gsalpha-cAMP signal axis and fasting blood glucose (FBG) in slight insulin resistance stage of HIgh Sugar High Fat-diet rats and diabetic db/db mice. The current finding thus suggested hepatic Gsalpha-cAMP signal axis plays a central role in regulating of FBG during the developing and development of T2DM. PMID: 28260721
2. Translocation of Galphas, which shows delayed onset after chronic antidepressant treatment of rats or of C6 glioma cells, tracks with the delayed onset of therapeutic action of antidepressants PMID: 27432886
3. Activated Galpha s translocates from the plasma membrane and, through interaction with tubulin/microtubules in the cytosol, is important for neurite formation, development, and outgrowth. PMID: 25691569
4. activated XLalphas and Galphas traffic differently, and this may form the basis for the differences in their cellular actions PMID: 21890629
5. Data show that the interdomain opening is coupled to receptor binding via the C-terminal helix of G(alpha), the extension of which is a high-affinity receptor binding element. PMID: 21606326
6. NESP55 has a role in a secreting vesicle pool found in the central and peripheral nervous system PMID: 12438142
7. Palmitoylation ensures proper localization of G-protein Galpha(s) to the plasma membrane and facilitates bimolecular interactions of Galpha(s) with the beta-adrenergic receptor and adenylyl cyclase. PMID: 12614155
8. expression of Galphas and Galphai protein subunits and adenylate cyclase in rat ovary, breast and pituitary are regulated by Luteinizing hormone-releasing hormone antagonist Cetrorelix PMID: 14767559
9. Gs subunits and beta2 androgen receptors utilize different internalization mechanisms. PMID: 15297467
10. PKA-mediated phosphorylation of the beta1-adrenergic receptor promotes Gs/Gi switching PMID: 15381255
11. Data suggest that alpha(1)-adrenoceptor stimulation reduces the amplitude of the I(to) by activating a G(alphas) protein and the cAMP/PKA signaling cascade, which in turn leads to I(to) channel phosphorylation. PMID: 15496483
12. a nucleotide-free state of Galphas is induced by Cu2+ and Zn2+ PMID: 15546818
13. Absence of Gsalpha imprinting in human bone and fat. Osteodystrophy and obesity in pseudohypoparathyroidism(PHP) Ia and PPHP(pseudo-PHP) patients despite presence of normal Gsalpha allele likely due to Gsalpha haploinsufficiency in these tissues. PMID: 15579796
14. data suggest that higher expression of somatostatin receptor subtype 1 and 2 mRNA induced by the gsp oncogene may be a mechanism by which gsp-positive tumors show a greater response to somatostatin PMID: 16379030
15. in rat preglomerular microvessels activation of A2AR is coupled to EET release upstream of adenylyl cyclase activation and EETs stimulate mono-ADP-ribosyltransferase, resulting in Gsalpha protein activation PMID: 16478979
16. Somatotroph adenomas in young patients seem to carry somatic Gs alpha mutations at a lower frequency, and germ-line or early postzygotic mutational events may be responsible for the shortened latency of tumorigenesis. PMID: 16631471
17. The switch to Gs coupling by MOR in response to chronic morphine, attenuated by opioid antagonist cotreatment, leads to a two-pronged stimulation of adenylyl cyclase utilizing both Galpha and Gbetagamma subunits of the Gs protein novel to this receptor. PMID: 16967511
18. The differential intracellular expression of NESP55-IR in spinal motoneurons and autonomic neurons suggests that NESP55 may be processed into different secretory granules and may be involved in both constitutive and regulated pathways in these neurons. PMID: 18067150
19. Data show that NESP55 positive neurons in the rat superior cervical ganglion project to a number of targets including the submandibular gland, the cervical lymph nodes, the forehead skin, the iris, but not to the thyroid. PMID: 18539096
20. Data demonstrated that activated Galpha(s) directly bound to tubulin and cellular microtubules, and fluorescence microscopy showed that cholera toxin-activated Galpha(s) colocalized with microtubules. PMID: 19237344

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UniGene: Rn.127731