Recombinant Rat Myc proto-oncogene protein (Myc)

Code CSB-YP015270RA
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Source Yeast
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Code CSB-EP015270RA
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Source E.coli
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Code CSB-EP015270RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP015270RA
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Source Baculovirus
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Code CSB-MP015270RA
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Myc
Uniprot No.
Alternative Names
Myc; Myc proto-oncogene protein; Proto-oncogene c-Myc; Transcription factor p64
Species
Rattus norvegicus (Rat)
Expression Region
1-439
Target Protein Sequence
MPLNVSFANR NYDLDYDSVQ PYFICDEEEN FYHQQQQSEL QPPAPSEDIW KKFELLPTPP LSPSRRSGLC SPSYVAVATS FSPREDDDGG GGNFSTADQL EMMTELLGGD MVNQSFICDP DDETFIKNII IQDCMWSGFS AAAKLVSEKL ASYQAARKDS TSLSPARGHS VCSTSSLYLQ DLTAAASECI DPSVVFPYPL NDSSSPKSCT SSDSTAFSSS SDSLLSSESS PRATPEPLVL HEETPPTTSS DSEEEQDDEE EIDVVSVEKR QPPAKRSESG SSPSRGHSKP PHSPLVLKRC HVSTHQHNYA APPSTRKDYP AAKRAKLDSG RVLKQISNNR KCSSPRSSDT EENDKRRTHN VLERQRRNEL KRSFFALRDQ IPELENNEKA PKVVILKKAT AYILSVQADE HKLISEKDLL RKRREQLKHK LEQLRNSGA
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release.
Gene References into Functions
  1. High c-myc expression is associated with liver fibrosis. PMID: 30243650
  2. C-myc gene silencing can promote cell proliferation and inhibit cell apoptosis and cytokine expression in IL-1beta-induced rat chondrocytes. PMID: 28616752
  3. demonstrated that RSV activated klf5 phosphorylation by inhibiting PI3K/PKD1/Akt pathway, and then attenuated the interaction of klf5 with c-Myc PMID: 29211809
  4. Dibutyl phthalate caused an increase in mRNA levels of c-Myc in the liver at all time points. DBP exerted biological activity through epigenetic modulation of c-Myc gene expression, it seems possible that dibutyl phthalate induced active demethylation of c-Myc gene through mechanism(s) linked to generation of reactive oxygen species by activated c-Myc. PMID: 24311629
  5. loss of inhibition on c-myc-Bmi-1-p16 signaling pathway by let-7g may lead to PASMCs proliferation and vascular remodeling in pulmonary hypertension PMID: 27889560
  6. JNK1 mediates pancreatic beta apoptotic cell death associated with increased Myc expression in IL1-beta treated cells. PMID: 26962537
  7. By inducing Myc expression in the colonic epithelium, lithium promotes colonic regeneration after DSS-induced colitis. PMID: 26320084
  8. Glucagon phosphorylates serine 552 of beta-catenin leading to increased expression of Ccnd1 and c-Myc in the isolated rat liver. PMID: 26135564
  9. Myc is critical in modulating the amplitude of cell cycle, whereas cyclin D/E activities have little effect on amplitude but do contribute to the modulation of duration of E2F1 activation, thereby affecting the pace of cell cycle progression. PMID: 25175461
  10. Activation of the ERK1/2 signalling pathway, increased phosphorylation of c-myc and significantly increased expression of cyclin D2 protein, are demonstrated. PMID: 25450615
  11. The study demonstrates the role of c-Myc as a central metabolic regulator and Bcl-2 and Akt assisting in extending c-Myc half-life as well as in regulation of autophagy, so as to regulate cell survival on the whole. PMID: 25056450
  12. Data indicate that c-Myc knockout cells preferentially utilize fatty acids as energy-generating substrates and reprogram other pathways to maximize acetyl-CoA and ATP production. PMID: 25053415
  13. Nol5a expands the link between Myc-induced regulation of nucleolar target genes PMID: 24013231
  14. Upregulation of Myc expression is associated with N-methyl nitrosourea induced rat mammary tumours. PMID: 24083763
  15. Bromodichloromethane decreases E-cadherin mRNA and increases that of c-myc and cyclin D1 in kidneys. PMID: 24001804
  16. Semiquantitative immunohistochemical analyses of Klf4, Sox2, c-Myc and Oct4 were studied in testes paraffin sections via light microscopy. PMID: 23828673
  17. the induction of ATF4/CHOP expression occurs via mTORC1 regulation of c-MYC and that this signaling pathway is a major determinant in the ability of bortezomib to induce apoptosis. PMID: 23612979
  18. Nanog and Klf4 antagonistically regulate c-Myc, and hence, cell hypoxia survival and cell cycle activation in experimental hepatoma. PMID: 23287475
  19. Cadmium may contribute to carcinogenesis by activating telomerase, and overexpressing the mRNAs of TERT, c-myc and p53, and causing apoptosis of normal hepatocytes. PMID: 21181359
  20. Overexpression of c-myc is associated with Acinar-to-ductal metaplasia in exocrine pancreatic cancer progression. PMID: 22024988
  21. Results suggest that c-myc is an important factor that promotes the proliferation of nucleus pulposus cells PMID: 21678465
  22. Results identified rapid-response genes likely to be direct c-Myc targets, and analyzed the promoters of the repressed genes to identify transcription factors that could be targets of c-Myc repression. PMID: 21623162
  23. Modest overexpression of cMyc is able to drive proliferation without cell death in normal rat and human beta-cells. PMID: 21885567
  24. PCB causes changes in the phenotype of the testis tissue, and the abnormal expressions of c-fos, c-Myc and beta-catenin are closely related to the PCB-induced testis injury. PMID: 21404708
  25. The activation and recruitment of ChREBP to several glucose-responsive genes were blocked by 1RH, indicating a general necessity for c-Myc in this process. PMID: 20382893
  26. The modulation of c-myc expression in testicles of rats treated with CS2 could be associated with lipid peroxidation induced by CS2. PMID: 17953200
  27. N-nitroso-N-methylurea disrupted and dietary methylselenocysteine significantly increased the expression of c-myc in mammary glands of Fischer 344 rats PMID: 20424134
  28. Huoxue Qianyang can inhibit the expression of c-myc in ventricular hypertrophy tissue. PMID: 18405607
  29. Positive expression of c-myc protein in some neurons was seen at 20 min after brain concussion. PMID: 17190142
  30. data demonstrate that MYC contributes to the activation of the ATM-dependent checkpoint responses, leading to cell death in response to specific genotoxic stimuli PMID: 20111719
  31. Data show that Myc repressed Ras-induced senescence, and that Cdk2 interacted with Myc at promoters, where it affected Myc-dependent regulation of genes, including those of proteins known to control senescence. PMID: 19966300
  32. Data demonstrate that polyamines regulate c-Myc translation in IECs through HuR phosphorylation by Chk2 and provide new insight into the molecular functions of cellular polyamines. PMID: 19812253
  33. Modulation of c-myc and c-fos gene expression in regenerating rat liver by 2-mercaptopropionylglycine PMID: 11846448
  34. expression in the brain during the first 3 weeks postexposure to impulse noise of 198 or 202 dB PMID: 11939505
  35. observations establish p27 as a physiologically relevant regulator of cyclin D-Cdk4/6 activity as well as mechanistically a target of c-Myc action PMID: 12070150
  36. Expression analysis and chromatin immunoprecipitation demonstrated that mitochondrial serine hydroxymethyltransferase is a direct Myc target gene, establishing a novel functional link between Myc and the regulation of cellular metabolism PMID: 12138190
  37. Transfected rat c-Myc functionally cooperates with Bax to induce apoptosis in mouse embryo fibroblasts. PMID: 12167710
  38. Augments the apoptotic activity of cytosolic death receptor signaling proteins by engaging the mitochondrial apoptotic pathway. PMID: 12202489
  39. This gene is required for the glucose-mediated induction of metabolic enzyme genes. PMID: 12480946
  40. c-Myc binds to TFIIIB, a pol III-specific general transcription factor, and directly activates pol III transcription PMID: 12529648
  41. c-myc expression leads to mitochondrial dysfunction and apoptosis by deregulating genes involved in mitochondrial function. PMID: 12533512
  42. Results suggest that c-Myc directly affects cell growth (accumulation of mass) and cell proliferation (the cell cycle machinery) by independent pathways. PMID: 12631706
  43. MYC recruits the TIP60 histone acetyltransferase complex to chromatin PMID: 12776177
  44. prolonged culture at low glucose partly results from early and sustained induction of beta-cell c-myc expression PMID: 14651961
  45. a model in which doxorubicin simultaneously triggers multiple c-Myc-dependent apoptosis pathways. PMID: 14990581
  46. c-myc transactivates rat and human adrenomedullin genes and accelerates the degradation rate of adrenomedullin mRNA PMID: 15192039
  47. a new mechanism by which Myc can silence gene expression not only by passive functional interference but also by active recruitment of corepressor proteins PMID: 15616584
  48. study of the nucleolar localization of hepatic c-Myc PMID: 15777849
  49. genetic analysis of the cascade of c-myc-activated genes PMID: 15867157
  50. The tumor-like proliferation of synoviocytes from AA rat joint might be related to the increased mRNAs of C-myc and ODC genes. PMID: 15989779

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Subcellular Location
Nucleus, nucleoplasm. Nucleus, nucleolus.
Database Links
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