Recombinant Rat Neuropilin-1(Nrp1) ,partial

Code CSB-YP879432RA
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Source Yeast
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Code CSB-EP879432RA
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Source E.coli
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Code CSB-EP879432RA-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP879432RA
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Source Baculovirus
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Code CSB-MP879432RA
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Nrp1
Uniprot No. Q9QWJ9
Alternative Names Nrp1; Neuropilin-1; Vascular endothelial cell growth factor 165 receptor; CD antigen CD304
Species Rattus norvegicus (Rat)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, the PLGF-2 isoform of PGF, the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. Regulates VEGFA-induced angiogenesis (By similarity). Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity).
Gene References into Functions
  1. important role in the regulation of neointimal hyperplasia by modulating vascular smooth muscle cell migration PMID: 26410366
  2. The results of the present study suggest that some soluble factors from smooth muscle cells may affect the localization of Nrp-1 in cholinergic neuronal cells, which may, in turn, be involved in the autonomic innervation of blood vessels. PMID: 25416424
  3. Nrp1-deficient vessels have reduced VEGFR2 surface expression in vivo demonstrating that NRP1 regulates its co-receptor, VEGFR2. PMID: 25244320
  4. The expressions of neuropilin-1 (NRP-1) on glioma cell lines and glioma tissues, were investigated. PMID: 23621014
  5. Neuropilin 1 (NPR1) and not Plexin A (PlexA), protein expression increased in the dorsal spinal cord of chronic constriction injury (CCI) rats. PMID: 20888378
  6. soluble recombinant rNRP-1 is a VEGF-A(165)-independent agonist of VEGFR-2 and stimulates angiogenesis in endothelial cells PMID: 20956519
  7. Neuropilin-1 mRNA showed no changed expression in axotomized motoneurons. PMID: 15094469
  8. NP-1 has a specific role in mediating neurotrophic actions of VEGF family members PMID: 15126502
  9. Data show that Npn-1 can potentiate the growth-stimulatory activity of FGF-2 on human umbilical vein endothelial cells, indicating that Npn-1 may not just bind but also regulate the activity of heparin-binding proteins. PMID: 15695515
  10. After spinal crush and rhizotomy, Np1 is expressed de novo around the injury and in the deafferentated dorsal horn, respectively, mainly by OX42-positive microglial cells. PMID: 15737738
  11. Nrp1 is a receptor for TGF-beta1, activates its latent form, and is relevant to regulatory T cell activity and tumor biology. PMID: 18436584

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Neuropilin family
Tissue Specificity Found in the embryonic nervous system.
Database Links

KEGG: rno:246331

STRING: 10116.ENSRNOP00000014492

UniGene: Rn.10815

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