Recombinant Tetronarce californica Acetylcholine receptor subunit alpha (CHRNA1), partial

The Recombinant Tetronarce californica CHRNA1 protein is a protein encoded by recombinant DNA that was cloned in an expression vector that supported the expression of CHRNA1 gene. This recombinant CHRNA1 protein was expressed in the host. The expression region is 25-234aa of the Tetronarce californica CHRNA1. In the production, the expression vector contains N-terminal 6xHis-SUMO tag. Every production step was performed with a strict QC system. The purity of this protein is 90%+ determined by SDS-PAGE.

Alpha 1 subunit of nAchRs, which is also called CHRNA1, belongs to muscle type nAchR, different from other neuronal alpha subunits nAchRs. CHRNA1 is detected its expression in NSCLC, and nicotine could activate its downstream MAPK and AKT signaling pathways to induce drug resistance. Additionally, CHRNA1 regulates the binding and gating of acetylcholine neurotransmitters, stood out due to its role in the sympathetic nervous system, which regulates the binding and gating of acetylcholine neurotransmitters, stood out due to its role in the sympathetic nervous system. Previously, dysregulated CHRNA1 levels were found to be associated with multiple neuromuscular disorders, such as congenital myasthenic syndrome, myasthenia gravis, and multiple pterygium syndrome. More importantly, the CHRNA1 gene expression has been found to be significantly higher in the thoracic sympathetic ganglia of patients with hand sweating than normal subjects. Acetylcholine blockers have been used to treat patients with primary focal hyperhidrosis, and the enhanced expression of CHRNA1 gene may be one of the mechanisms underlying excessive sweat secretion. Recently many reports have focused on nAchR inhibitors as target agents for cancer therapy. CHRNA1, a subunit of nAchRs expressed in lung cancer patients, should be the target of cancer therapeutic development for improving the cure rate or for preventing recurrence and prolonging patient survival.