Recombinant Xenopus laevis Stromal cell-derived factor 1(cxcl12)

Code CSB-YP844964XBE
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Source Yeast
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Code CSB-EP844964XBE
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Source E.coli
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Code CSB-EP844964XBE-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP844964XBE
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Source Baculovirus
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Code CSB-MP844964XBE
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names cxcl12
Uniprot No. Q8UUJ9
Alternative Names cxcl12; sdf1; Stromal cell-derived factor 1; xSDF-1; C-X-C motif chemokine 12
Species Xenopus laevis (African clawed frog)
Expression Region 22-94
Target Protein Sequence KPVSLVYRC PCRYFESNVP KSNIKHLKIL STSNCSLQIV ARLKHNGKQI CLDPKTKWIQ EYLEKALNKK AKKT
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Chemoattractant. Activates the C-X-C chemokine receptor cxcr4 to induce a rapid and transient rise in the level of intracellular calcium ions, and chemotaxis. Signaling with cxcr4 mediates the directional movement of mesodermal cells during gastrulation.
Gene References into Functions
  1. These findings support the conservation of sdf-1alpha signaling in vertebrate somite morphogenesis; however, the precise mechanism by which this signaling pathway influences somite morphogenesis is different between the fish and the frog. PMID: 24357195
  2. SDF-1/CXCR4 chemokine signaling is involved in the migration and survival or in the differentiation of PGCs in Xenopus PMID: 19770040
  3. A significant increase of stromal cell-derived factor-1alpha and CXCR4 was observed in protein extracts of idiopathic inflammatory myopathies in comparison with normal controls. PMID: 15019705
  4. SDF-1 signaling is necessary for migrations of massive numbers of cells during gastrulation. PMID: 17239342
Subcellular Location Secreted
Protein Families Intercrine alpha (chemokine CxC) family
Tissue Specificity Isoform alpha is expressed throughout the inner deep cells of the blastocoel roof during gastrula stage embryos. Isoform beta is expressed in the developing central nervous system (CNS) of embryos; at stages 21-23, up-regulated in the anterior of the embr
Database Links

KEGG: xla:399030

UniGene: Xl.4813

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