CXCL12 Research Reagents

Stromal cell-derived factor 1 is a protein in humans that is encoded by CXCL12 gene. Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase.

The following CXCL12 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

CXCL12 Antibodies

CXCL12 Antibodies for Homo sapiens (Human)

CXCL12 Proteins

CXCL12 Proteins for Mus musculus (Mouse)

CXCL12 Proteins for Homo sapiens (Human)

CXCL12 Proteins for Felis catus (Cat) (Felis silvestris catus)

CXCL12 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

CXCL12 Proteins for Xenopus laevis (African clawed frog)

CXCL12 ELISA Kit

CXCL12 ELISA Kit for Homo sapiens (Human)

CXCL12 ELISA Kit for Mus musculus (Mouse)

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