Recombinant Human 3-hydroxy-3-methylglutaryl-coenzyme A reductase(HMGCR) ,partial

Code CSB-YP010565HU
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Source Yeast
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Code CSB-EP010565HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP010565HU
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Source Baculovirus
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Code CSB-MP010565HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names HMGCR
Uniprot No. P04035
Research Area Metabolism
Alternative Names 3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Hmgcr; Hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269; Red
Species Homo sapiens (Human)
Mol. Weight 36.1kD
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Datasheet Please contact us to get it.

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Target Data

Function Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
Gene References into Functions
  1. High HMGR expression is associated with breast cancer metastasis. PMID: 29626418
  2. High HMGCR expression is associated with hypercholesterolemia. PMID: 29678744
  3. The presence of rs17244841 ve rs17238540 mutations in HMGCR causes a significant reduction in total cholesterol and LDL-c levels. PMID: 29096742
  4. A positive relationship emerged between HMG-CoAR, hormone receptors and TAZ/YAP, suggesting a connection between the mevalonate pathway, the hormonal milieu and Hippo in Male breast cancer. Moreover, HMG-CoAR expression may be a favorable prognostic indicator. PMID: 27713571
  5. HMGCR genetic variation is associated with Alzheimer's disease. PMID: 26950278
  6. our study demonstrates A allele of HMGCR rs3846662 acts as a protective factor for late-onset Alzheimer's disease in northern Han Chinese PMID: 27009838
  7. UBXD8 is necessary for sterol-stimulated dislocation of ubiquitylated HMGCR from the endoplasmic reticulum membrane en route to proteasomal degradation, a function dependent on its UBX domain. PMID: 28882874
  8. The docking studies indicate rutin as the best compound that can inhibit HMG-CoA reductase as it had strong binding affinity to the enzyme. PMID: 27216569
  9. Both HMGCR and SQLE promoters have two SREs that may act as a homing region to attract a single SREBP-2 homodimer. PMID: 28342963
  10. To estimate the association between changes in levels of LDL-C (and other lipoproteins) and the risk of cardiovascular events related to variants in the CETP gene, both alone and in combination with variants in the 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) gene. PMID: 28846118
  11. Low LDL cholesterol levels due to PCSK9 and HMGCR variants had no causal effect on high risk of Alzheimer's disease, vascular dementia, any dementia, or Parkinson's disease; however, low LDL cholesterol levels may have a causal effect in reducing the risk of Alzheimer's disease. PMID: 28438747
  12. TGF-beta1 induces cholesterol synthesis by increasing HMG-CoA reductase mRNA expression in keratinocytes. PMID: 26932266
  13. Gene expression profile and the biological functions of HMGCR in gastric cancer were studied. It was found that the expression of HMGCR was increased in gastric cancer tissues. Over-expression of HMGCR promoted the growth and migration of gastric cancer cells, while knocking down the expression of HMGCR inhibited the growth, migration and tumorigenesis of gastric cancer cells. PMID: 27085483
  14. In this study, variants in PCSK9 had approximately the same effect as variants in HMGCR on the risk of cardiovascular events and diabetes per unit decrease in the LDL cholesterol level. The effects of these variants were independent and additive. PMID: 27959767
  15. Data show that simvastatin significantly inhibited cellular proliferation, induced cell cycle G1 arrest and apoptosis, and caused cellular stress via reduction in the enzymatic activity of 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMGCR). PMID: 26503475
  16. no associations found between HMGCR rs3846662, HMRCR alternative splicing and Alzheimer's disease pathology pathology. PMID: 26541602
  17. results indicate that abnormal lipid metabolism may exist in spontaneous preterm delivery (SPTD) women and the premature fetus and the HMGCR gene may be a susceptible gene for SPTD PMID: 26301579
  18. Report the mechanism of polyphenol binding to and activity regulation of HMGR using molecular docking. PMID: 26357462
  19. the results of the present study showed that luteolin modulates HMGCR transcription by decreasing the expression and nuclear translocation of SREBP-2. PMID: 26302339
  20. Discovery new drug candidates for inhibition of human HMG-CoA reductase through structure-based virtual screening. PMID: 26170618
  21. Results show that HMGCR rs3846662 acts as a potent genetic modifier for Alzheimer's disease risk, age of onset and conversion from mild cognitively impairment PMID: 25023145
  22. study demonstrated the oncogenic roles of HMGCR in glioblastoma cells and HMGCR might be a promising therapeutic target. PMID: 26432005
  23. the 5-aminoimidazole-4-carboxyamide ribonucleoside (AICAR)-induced activation of AMPK directly inhibited the expression of SREBP-2 and HMGCR and HMGCS, and suppressed the TSH-stimulated up-regulation of SREBP-2 in HepG2 cells. PMID: 25933205
  24. Data show that sterols stimulate binding of prenyltransferase UBIAD1 to HMG CoA reductase, which is subject to sterol-accelerated, endoplasmic reticulum (ER)-associated degradation augmented by the nonsterol isoprenoid geranylgeraniol. PMID: 25742604
  25. Human carotid atherosclerotic lesion protein components decrease cholesterol biosynthesis rate in macrophages through 3-hydroxy-3-methylglutaryl-CoA reductase regulation. PMID: 25639207
  26. miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR PMID: 25605429
  27. The effect of lower LDL-C on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both is approximately the same per unit lower LDL-C and log-linearly proportional to the absolute exposure to lower LDL-C. PMID: 25770315
  28. promoter DNA hypermethylation of the ABCG1 and GALNT2 genes, but not the HMGCR gene, is associated with an increased risk of CHD. PMID: 25084356
  29. Strong HMGCR expression is associated with high response to radiotherapy in ductal carcinoma-in situ. PMID: 24777857
  30. The results show that carriage of SNPs in the HMGCR gene were associated with bodyweight gain and increased risk of type 2 diabetes PMID: 25262344
  31. HMGCR is differentially expressed in colorectal cancer and that positive expression is associated with favourable tumour characteristics and a prolonged survival in unadjusted analysis. PMID: 24708688
  32. HMGCR is upregulated in hepatocellular carcinoma associated with paraneoplastic hypercholesterolemia. PMID: 23549978
  33. findings show that HNRNPA1 modulates the expression level of an alternatively spliced transcript of HMGCR by regulating splicing and altering RNA stability, resulting in reduced HMGCR enzyme activity and increased LDL-Cholesterol uptake PMID: 24001602
  34. Data indicate that RNAi-mediated knockdown of VCP/p97 blocks sterol-accelerated degradation but not ubiquitination of 3-hydroxy-3-methylglutaryl coenzyme A reduc (HMG CoA reductase) in SV-589 cells. PMID: 24025715
  35. HMGCR-mediated changes in F-actin structure play an important role in the inter-cellular transmission of respiratory syncytial virus infection. PMID: 23994498
  36. Over-expression of HMGCR in esophageal squamous cell carcinoma (ESCC) cells promoted cell growth and migration. PMID: 24390662
  37. knockdown of MARCH6 also controls the level of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase (HMGCR) in hepatocytes and model cell lines PMID: 24449766
  38. Increased cholesterol synthesis mediated by HMGCoA-R under inflammatory stress may be one of the mechanisms for intracellular lipid accumulation and statin resistance. PMID: 24233489
  39. Age and sex modify the contribution of the HMGCR-911 polymorphism to fasting serum total cholesterol, LDL-cholesterol levels and risk of coronary heart disease. PMID: 23933271
  40. These results suggest that dengue virus infection increases intracellular cholesterol levels at early times post infection by triggering the modulation of LDL particles uptake and the increase in the enzymatic activity of HMG-CoA reductase. PMID: 23642566
  41. A novel role for Aup1 in maintenance of intracellular cholesterol homeostasis via mediation of the endoplasmic reticulum associated degradation of HMG-CoA reductase. PMID: 23223569
  42. Statins up-regulate the expression of HMGCR, the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. PMID: 21360500
  43. The association of HMGCR promoter region polymorphisms with cholesterol levels and coronary artery disease in patients from Western India are reported. PMID: 22858685
  44. This study was designed to understand the mode of interactions of HMGCR isoform 2 with statins Atorvastatin, Lovastatin, Fluvastatin, Simvastatin, Pravastatin, Rosuvastatin and Cerivastatin. PMID: 22177940
  45. The HMGCR rs3846662 GG genotype was quantitatively documented to be a significant determinant for higher LDL-C level in basal state and possibly in response to atorvastatin. PMID: 21427285
  46. Reductions in plasma insulin may have affected the expression of a key regulatory gene of cholesterol synthesis, HMG-CoA reductase and low-density lipoprotein receptor. PMID: 22024489
  47. HMG-CoA reductase activation and urinary pellet cholesterol elevations in acute kidney injury. PMID: 21799150
  48. HMG-CoA reductase regulation takes place at the levels of transcription, translation, post-translational modification and degradation. (Review) PMID: 21801748
  49. Linalool reduces the expression of 3-hydroxy-3-methylglutaryl CoA reductase via sterol regulatory element binding protein-2- and ubiquitin-dependent mechanisms. PMID: 21944868
  50. inhibition of protein geranylgeranylation markedly attenuated ubiquitylation and dislocation, implicating for the first time a geranylgeranylated protein(s) in the metabolically regulated ERAD of HMGR. PMID: 21778231

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Subcellular Location Endoplasmic reticulum membrane, Multi-pass membrane protein
Protein Families HMG-CoA reductase family
Database Links

HGNC: 5006

OMIM: 142910

KEGG: hsa:3156

STRING: 9606.ENSP00000287936

UniGene: Hs.628096

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