Code | CSB-RA555022A0HU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The ACVRL1 recombinant monoclonal antibody is a valuable tool for detecting human ACVRL1 protein in ELISA, WB, and IHC applications, which is produced using recombinant DNA technology. To produce the ACVRL1 recombinant monoclonal antibody, the cDNA of the ACVRL1 antibody-producing hybridomas is sequenced, and the gene coding for the ACVRL1 antibody is synthesized. The hybridomas are generated by fusing myeloma cells with B cells that are extracted from animals immunized with a synthesized peptide derived from human ACVRL1. The synthesized gene is then inserted into a vector, which is subsequently transfected into cells for cultivation. Finally, the ACVRL1 recombinant monoclonal antibody is purified from the cell culture supernatant using affinity chromatography.
The ACVRL1 protein, also known as ALK1 (activin receptor-like kinase 1), is a type I cell-surface receptor for the TGF-beta superfamily of signaling proteins. It is mainly expressed in endothelial cells and plays a critical role in the development and maintenance of the cardiovascular system. In particular, ACVRL1 regulates the proliferation, migration, and differentiation of endothelial cells, as well as the recruitment and activation of smooth muscle cells and pericytes. It also plays a role in the maintenance of vascular homeostasis and angiogenesis. Mutations in the ACVRL1 gene have been associated with hereditary hemorrhagic telangiectasia (HHT).
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