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FGFR3 is a tyrosine kinase receptor that can bind to fibroblast growth factors, triggering a cascade of downstream signals that affect cell growth, migration, angiogenesis, and differentiation. FGFR3 suppresses chondrocyte proliferation in the growth plate and limits bone elongation. Genetic instability and aneuploidy have been linked to FGFR3 mutations. In growth plate chondrocytes, gain-of-function FGFR3 mutations produce dwarfism, lower telomerase activity, and shorter telomeres, implying that FGFR3 diminishes proliferative ability, represses telomerase, and accelerates senescence.The recombinant FGFR3 antibody was generated in vitro through inserting cloned FGFR3 genes into expression vectors. The expression vector was then inserted into a mammalian cell to express this FGFR3 antibody. It has been validated in ELISA, IF. Every step in the production was controlled strictly. You have no worries about the quality.
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