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The first step in the preparation of recombinant HDAC3 antibody is to obtain the HDAC3 antibody gene. The heavy and light chain genes of the antibody were constructed into a plasma vector and then transfected into suspended mammalian cells transiently. After expression verification, cell supernatant was collected in expanded culture and purified recombinant HDAC3 antibody was obtained using affinity-chromatography. This recombinant HDAC3 antibody has been validated for the detection of HDAC3 protein from Human in the ELISA, WB, IHC.
HDAC3 is involved in the regulation of gene transcription, chromatin remodeling, and genomic stability. Under physiological conditions, HDAC3 contributes to modulating rhythms, metabolism, and development. The involvement of HDAC3 has been found in various diseases, including ischemic injury, fibrosis, neurodegeneration, infections, and inflammatory conditions. HDAC3 is required for lymphopoiesis and hematopoietic cell fate decisions. Studies have shown that HDAC3 influences cancer cell responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential in interaction with cancer-associated genes (CAGE), specifically the cancer/testis antigen gene.
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