Code | CSB-RA941933A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
There are four key steps during the production of an ISL1 recombinant antibody. Sequencing the ISL1 monoclonal antibody gene, cloning the gene into a plasmid vector, introducing the recombinant vector into a host cell line, and purifying the ISL1 recombinant monoclonal antibody from the cell culture supernatant using affinity chromatography. The ISL1 monoclonal antibody is derived from ISL1 antibody-producing hybridomas, and a synthesized peptide derived from human ISL1 is used as an immunogen during the production of the ISL1 monoclonal antibody. This recombinant monoclonal antibody is suitable for use in ELISA, WB, and IHC applications to detect human ISL1 protein.
The ISL1 protein is a transcription factor that plays a critical role in the development of the nervous system and the heart. In the nervous system, ISL1 is involved in the differentiation and survival of motor neurons, sensory neurons, and sympathetic neurons. In the heart, ISL1 is expressed in cardiac progenitor cells and regulates their proliferation, differentiation, and survival. ISL1 is also important for the development of the pancreas and the adrenal gland. Abnormal expression of ISL1 has been associated with various developmental disorders and cancers.
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