PRLR (rolinsatamab) Recombinant Monoclonal Antibody

1. In a replication study of the association between the prolactin receptor gene intron C/T polymorphism (rs37389) and recurrent miscarriage, no association was found. PMID: 28980840
2. Low PRLR expression is associated with Triple Negative Breast Cancer. PMID: 27480353
3. These results illustrate promising antitumor activity against PRLR-positive breast cancer xenografts and support the evaluation of anti-PRLR antibody-drug conjugate as potential therapeutic agents in breast cancer. PMID: 28377489
4. Prl receptor is expressed at different levels in the majority of glioblastoma multiforme tumors. Prolactin stimulation resulted in increased STAT5 phosphorylation and increased cellular invasion. PMID: 27788487
5. PRLRI146L and PRLRI176V variants are not associated with breast cancer or multiple breast fibroadenomas risk. PMID: 27575941
6. This study identified 4 PRLR variations (p.Ile76Val, p.Ile146Leu, p.Glu108Lys and p.Glu554Gln) in 16 Sporadic Prolactinoma in Humans. PMID: 26641246
7. results highlight PRLR as an independent predictor of favorable prognosis in human breast cancer PMID: 26317306
8. Two markers for the PRL peptide gene and three markers for the prolactin receptor (PRLR) gene were genotyped. PMID: 26513615
9. The prolactin receptor is constitutively expressed on regulatory T and effector T cells in systemic lupus erythematosus patients, and this expression is higher than in healthy individuals. PMID: 26844452
10. There is a possible role for PRLR in the progression of cervical cancer. PMID: 24990775
11. Study shows that position 146 plays a central role in directing intrinsic properties of the PRLR, including extracellular domain folding, PRL-responsiveness, and ligand-independent activity of the receptor. PMID: 25524456
12. Data suggest that (1) cell membrane/lipid bilayer binding of PRLR and (2) tyrosine phosphorylation of PRLR intracellular domain are independent. PMID: 25846210
13. long PRLR plays an important role in breast cancer metastasis. PMID: 26095602
14. a residue quartet in the extracellular membrane proximal domain of the homodimeric cytokine receptor prolactin receptor is a key regulator of intracellular signaling discrimination PMID: 25784554
15. PRL induced transient signaling pathways in neurons and modulated ion channels. [review] PMID: 24758841
16. exposure to prolactin increases TNF-alpha release from CD14(+) monocytes of rheumatoid arthritis patients, which can be abolished by PRLR gene silencing or treating with MAPK inhibitor. PMID: 24997655
17. High MFAB expression is associated with testicular germ cell tumor and glioblastomas. PMID: 24391856
18. Negative/low expression is associated with poorly differentiated and larger breast tumors in Poland PMID: 24249584
19. Major changes in prolactin receptor conformation and dimerization affinity are triggered by single mutations in critical regions of D1. PMID: 24735798
20. PRL-R attenuation post-transcriptionally increased ZnT2 abundance and redistributed intracellular Zn pools into lysosomes and mitochondria. PMID: 24333596
21. Hypertrimethylation on H3K27 of the p53 gene promoter region due to elevated expression of DeltaS2 PRLR by alternative splicing of the pre-mRNA in its full-length form might serve as a new mechanism underlying prostate cancer PMID: 24032713
22. Data suggest that signal transduction via prolactin and prolactin receptor plays role in trophoblast cell migration and invasion; PRLR is expressed by extravillous cytotrophoblasts and first-trimester placental bed tissue. PMID: 23849393
23. PRL-induced transient signaling in sensory neurons is governed by PI3K or PKCepsilon, mediated via the PRLR-S isoform, and transient effects mediated by PRLR-S are inhibited by presence of PRLR-L in these cells. PMID: 24142695
24. SNPs of the PRLR gene 5' UTR and promoter region are associated with increased risk for gestational diabetes in a population of Chilean subjects. PMID: 23651351
25. Thus, the familial hyperprolactinemia appears to be due to a germline, loss-of-function mutation in PRLR, resulting in prolactin insensitivity. PMID: 24195502
26. Results demonstrate a novel function for hepatic PRLR in the regulation of insulin sensitivity and provide important insights concerning the nutritional regulation of PRLR expression. PMID: 23775766
27. Our data suggest that prolactin receptor presence meaningfully affects growth hormone receptor use in breast cancer cells. PMID: 23192981
28. The prolactin receptor transactivation domain is associated with steroid hormone receptor expression and malignant progression of breast cancer PMID: 23159947
29. Our results indicate no significant association of prolactin and PRLR polymorphisms with clozapine response, tardive dyskinesia diagnosis or its severity in patients with schizophrenia PMID: 21305610
30. can be activated by three sequence-diverse human hormones: prolactin, GH, and placental lactogen [review] PMID: 22577091
31. PRLr isoforms expression and PRLr subcellular localisation are altered in parathyroid tumours PMID: 22606260
32. The structure of the human prolactin receptor reveals a structural link between the WSXWS motif, hormone binding, and receptor dimerization and we propose it as a general mechanism for class 1 receptor activation. PMID: 22325776
33. PRL signaling through the long form prolactin receptor causes reduced fatty acid oxidation, increased lipid storage, glucose intolerance, and obesity. PMID: 21989556
34. data provide limited support for an association between common variations in PRLR and breast cancer risk PMID: 21470416
35. The association of the PRLr with HMGN2 enables Stat5a-responsive promoter binding, thus facilitating transcriptional activation and promoting anchorage-independent growth. PMID: 21816901
36. Our study suggests the prolactin receptor gene is a molecular target that may be important in the pathogenesis and progression of lobular neoplasia PMID: 20658264
37. Enhanced complex formation of ERalpha dimer with SP1 and C/EBPbeta by E2 has an essential role in the transcriptional activation of the hPRLR gene. PMID: 21670145
38. Data show that cells expressing higher long:short PRLR ratios had increased growth, survival and migration in response to PRL and suggest that PRLR antagonists may be therapeutically beneficial in ovarian cancer. PMID: 21775057
39. Endogenous GH receptor(GHR) and PRLR associate, possibly as a GHR-PRLR heterodimer, in human breast cancer cells and GH signaling in these cells is largely mediated by the PRLR in the context of both PRLR-PRLR homodimers and GHR-PRLR heterodimers. PMID: 21310852
40. The positive correlations in positivity rate between the PRL-R and ER/PR expressions are found only in CerbB-2 positive patients with breast cancer. PMID: 20335148
41. SIRPalpha modulates PRL receptor-associated signaling as a function of integrin occupancy by mediating integrin-PRL receptor cross-talk and contributing to breast cancer biology. PMID: 20826546
42. both Zn(2+) and human PRLr binding influence human PRL conformers in an interdependent fashion PMID: 21510945
43. Functional impact of manipulation on the relative orientation of human prolactin receptor domains. PMID: 21591677
44. Progesterone induces expression of the prolactin receptor gene through cooperative action of Sp1 and C/EBP transcription factors PMID: 21238538
45. Rabbit antibodies have high titer and could specifically recognize each isoform of PRLR in breast cancer cell lines and human breast carcinoma biopsies. PMID: 21144038
46. Prolactin receptor signaling contributes to the local inflammatory response within the atherosclerotic plaque and thus to atherogenesis. PMID: 21068074
47. Blockade of the PRLR represents a novel treatment for patients with advanced breast or prostate cancer with limited therapeutic options. PMID: 20846877
48. acetylation and deacetylation provide the rheostat-like regulation for the cytokine receptor PRLR in its cytoplasmic loop dimerization and subsequent STAT5 activation PMID: 20962278
49. This study allowed to visualize for the first time the loop L5 spanning PRLR2 residues Thr133-Phe140, revealing its central implication for the three intermolecular interfaces of the 1:2 complex between natural prolactin and two PRLR chains. PMID: 20875426
50. prolactin receptor expression is common in colorectal cancer PMID: 20453834

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HGNC: 9446

OMIM: 176761

KEGG: hsa:5618

STRING: 9606.ENSP00000371432

UniGene: Hs.368587