Code | CSB-RA010097A139phHU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The synthesized DNA sequence corresponding to the phospho-Histone H2AX (S139) monoclonal antibody was cloned into the plasmid and then transfected into the cell line for expression. The monoclonal antibody against phospho-Histone H2AX (S139) was generated from the animals immunized by phospho-peptide containing human Histone H2AX S139 site. The product was purified through the affinity-chromatography method and obtained the phospho-Histone H2AX (S139) recombinant monoclonal antibody. This phospho-Histone H2AX (S139) recombinant antibody is a rabbit IgG and has been tested in scientific applications, including ELISA, WB, and IHC. It only recognizes phosphorylated serine 139 of human H2AX.
The S139 phosphorylated H2AX, also termed γH2AX, is a sensitive marker for DNA double-strand breaks (DSBs) and is responsible for the recruitment of cell cycle checkpoint and DNA repair factors to the damaged site.
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