Code | CSB-RA051594A0HU |
Size | US$210 |
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Application | Recommended Dilution |
---|---|
IHC | 1:50-1:200 |
FC | 1:50-1:200 |
The phospho-MAPT (S199) recombinant monoclonal antibody expression typically involves the initial step of inserting the MAPT antibody-encoding gene into expression vectors. These vectors are then introduced into host cells using polyethyleneimine-mediated transfection. Culturing of the host cells leads to the production and secretion of the antibodies. Post-affinity chromatography purification, the antibodies' functionality is assessed through ELISA, IHC, and FC tests, confirming their capacity to recognize the human MAPT protein phosphorylated at S199.
MAPT phosphorylated at S199 is intimately involved in microtubule regulation, neuronal morphology, and its association with neurodegenerative diseases, particularly Alzheimer's disease and tauopathies.
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