Code | CSB-RA019025A542phHU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
IP | 1:200-1:1000 |
The product CSB-RA019025A542phHU is a recombinant GDNF monoclonal antibody. It was generated by transfecting the human phospho-PTPN11 (Y542) monoclonal antibody gene-vector clones into the cell line for in vitro production and subsequent purification from the tissue culture supernatant (TCS) through affinity-chromatography. This phospho-PTPN11 (Y542) antibody is reactive with human PTPN11 phosphorylated at Y542. And it has been tested for use in multiple applications, including ELISA, WB, and IP.
PTPN11, also known as Shp2, is a widely expressed protein tyrosine phosphatase, and its kinase-induced hyperactivity has been linked to a variety of cancers. RTKs like EPHA2 phosphorylate Y542 and Y580 on PTPN11, which prolongs ERK activation by keeping PTPN11 in an open conformation. According to studies, phosphorylated Y542 interacts intramolecularly with the N-SH2 domain of Shp2 to relieve PTPase basal inhibition, whereas phosphonate at Y580 enhances PTPase activity through interacting with the C-SH2 domain.
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