Code | CSB-RA019386A807phHU |
Size | US$210 |
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Application | Recommended Dilution |
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IF | 1:20-1:200 |
The DNA coding for the human monoclonal antibody against synthetic phosphopeptide of RB1 (S807) was integrated into the plasmid and then transfected into the cell line for in vitro expression. After purification from the tissue culture supernatant (TCS) through affinity-chromatography, the product recombinant monoclonal phospho-RB1 (S807) antibody was isolated. This phospho-RB1 Ser807 antibody detects endogenous RB1 protein only when phosphorylated at Serine 807. It is a rabbit IgG and is reactive with human samples. And it is suitable for ELISA and IF analyses.
RB1 gene is the first isolated tumor suppressor gene in human. It is a negative regulator of the cell cycle and regulates the expression of genes required for cell proliferation and differentiation by binding with transcription factor E2F1, thus maintaining the balance of cell growth and development. Therefore, the function of the RB1 gene is related to the cell cycle, cell senescence, cell apoptosis, cell differentiation, and growth inhibition. In general, Rb1 phosphorylation is required to release transcriptional target inhibition and promote cell cycle progression.
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