Code | CSB-RA026244A127phHU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
IHC | 1:50-1:200 |
The synthesized DNA sequence corresponding to the pS127-YAP1 monoclonal antibody was cloned into the plasmid and then transfected into the cell line for expression. The product was purified through the affinity-chromatography method and obtained the specifically phosphorylated YAP1 recombinant monoclonal antibody. This anti-S127-YAP1 recombinant antibody is a rabbit IgG and has been tested in scientific applications, including ELISA, WB, and IHC. It only reacts with human YAP1 phosphorylated at Ser 127 residue.
The transcriptional coactivator YAP1 is involved in cell proliferation, cell-cell interactions, organ size, and tumorigenesis. YAP1's nuclear activity is dependent on post-transcriptional changes and nuclear translocation. Androgen reduces Androgen attenuates the inactivating phospho–Ser-127 modification of YAP1 and promotes YAP1 nuclear abundance and activity. The traditional Hippo kinase cascade is known to phosphorylate YAP1 at Ser127, which is required for its cytoplasmic localization and inactivation.
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