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| Code | CSB-RA213020A0HU |
| Size | US$210 |
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| Application | Recommended Dilution |
|---|---|
| IHC | 1:50-1:200 |
The preparation of the SCIN recombinant monoclonal antibody involves a genetic engineering process that includes cloning and expression of the gene encoding for the SCIN monoclonal antibody. The synthesized peptide derived from the human SCIN protein was used as the immunogen to generate the SCIN monoclonal antibody. The obtained MAS1L recombinant monoclonal antibody underwent purification using affinity chromatography to ensure high purity. It has been validated for use in human samples and can specifically recognize and bind to the SCIN protein. Quality and specificity testing of the SCIN recombinant monoclonal antibody have been carried out using ELISA and IHC applications.
SCIN is a calcium-dependent actin-severing protein that is involved in regulating actin dynamics in cells. It is expressed in various cell types including muscle cells, platelets, and neurons, and has been shown to play a role in diverse cellular processes such as cell migration, cytokinesis, and neurite outgrowth. SCIN is thought to interact with actin filaments and sever them into shorter segments, which can then be used as building blocks for other actin structures. Additionally, SCIN has been implicated in regulating the formation of dendritic spines in neurons, which are important for synaptic transmission and plasticity.
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