SCIN Antibody

Datasheet

Code	CSB-PA020823LA01HU
Size	US$166
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Image	Western Blot Positive WB detected in: Mouse stomach tissue All lanes: SCIN antibody at 3.5μg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 81, 66, 53 kDa Observed band size: 81 kDa Immunofluorescent analysis of HepG2 cells using CSB-PA020823LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) SCIN Polyclonal antibody

Uniprot No.

Q9Y6U3

Target Names

SCIN

Alternative Names

Adseverin antibody; ADSV_HUMAN antibody; KIAA1905 antibody; Scin antibody; Scinderin antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Recombinant Human Adseverin protein (556-703AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The SCIN Antibody (Product code: CSB-PA020823LA01HU) is Non-conjugated. For SCIN Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA020823LB01HU	SCIN Antibody, HRP conjugated	ELISA
FITC	CSB-PA020823LC01HU	SCIN Antibody, FITC conjugated
Biotin	CSB-PA020823LD01HU	SCIN Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, WB, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IF	1:50-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles. Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts. Regulates chondrocyte proliferation and differentiation. Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways.

Gene References into Functions

Data suggest that scinderin (Scin) played a vital role in the development of developmental dysplasia of the hip (DDH). PMID: 28213129
Epistasis analysis identified a statistically significant interaction between CDC42 and SCIN SNPs which are strongly associated with CDC42 and SCIN gene expression levels and map to regulatory elements in skin cells. This interaction has important biological relevance since CDC42 and SCIN proteins have opposite effects in actin cytoskeleton organization and dynamics, which underlies melanoma cell migration and invasion. PMID: 27347659
High levels of SCIN expression in gastric cancer tissue correlate with poor prognosis of patients. SCIN enhances the invasion and metastasis of GC cells through activating the Cdc42 pathway to increase the formation of filopodia. PMID: 27033455
Suppression of scinderin impairs proliferation and migration of gastric cancer SGC7901 cells and attenuates its epithelialmesenchymal transition process. PMID: 25174406
SCIN plays an important role in lung carcinoma cell proliferation PMID: 25303873
These results suggest that SCIN plays an important role in the proliferation of prostate cancer cells and lentivirus-mediated inhibition of SCIN expression may be a potential therapeutic method for the treatment of prostate cancer PMID: 24212916
Scinderin expression does not correlate with prognosis in head and neck cancer. PMID: 24330498
calcium binding to the N terminus of adseverin dominates the activation process to expose the F-actin binding site on A2 PMID: 19666531

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Subcellular Location

Cytoplasm, cytoskeleton. Cell projection, podosome.

Protein Families

Villin/gelsolin family

Tissue Specificity

Expressed in megakaryocytes.

Database Links

HGNC: 21695

OMIM: 613416

KEGG: hsa:85477

STRING: 9606.ENSP00000297029

UniGene: Hs.633359

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Related pathways

Regulation of actin cytoskeleton Fc gamma R-mediated phagocytosis

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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