Code | CSB-RA835707A2HU |
Size | US$210 |
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Application | Recommended Dilution |
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FC | 1:50-1:200 |
The SEMA4D recombinant monoclonal antibody is generated using a multi-step process. Firstly, the SEMA4D monoclonal antibody is collected, and its gene sequence is determined. Next, a vector containing the SEMA4D monoclonal antibody gene is created and transfected into a host cell line for culture. During the SEMA4D monoclonal antibody synthesis, a recombinant human SEMA4D protein is used as an immunogen. The SEMA4D recombinant monoclonal antibody is then purified through affinity chromatography and assessed for specificity using ELISA and FC applications. It can react with human and mouse SEMA4D proteins.
The SEMA4D protein plays a role in cell-cell communication and is involved in various cellular processes such as axon guidance, angiogenesis, and immune response. It acts as a ligand for the receptor plexin-B1 and also binds to the integrin receptor alpha-v beta-1. SEMA4D regulates cell migration, proliferation, and survival by modulating intracellular signaling pathways, including the Rho GTPase pathway and the Akt/mTOR pathway. It is also involved in cancer progression and metastasis by promoting tumor cell invasion and angiogenesis.
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