Recombinant Human Cyclic AMP-dependent transcription factor ATF-6 alpha(ATF6)

Code CSB-CF002277HU(A4)
Product Type Transmembrane Protein
Size Pls inquiry other sizes
Uniprot No. P18850
Storage Buffer Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Species Homo sapiens (Human)
Source in vitro E.coli expression system
Gene Names ATF6
Protein Names Recommended name: Cyclic AMP-dependent transcription factor ATF-6 alpha Short name= cAMP-dependent transcription factor ATF-6 alphaAlternative name(s): Activating transcription factor 6 alpha Short name= ATF6-alphaCleaved into the following ch
Expression Region 1-670
Tag Info N-terminal 10xHis-tagged
Protein Description full length protein
Storage Store at -20°C, for extended storage, conserve at -20°C or -80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.
Involvement in disease Achromatopsia 7 (ACHM7)
Subcellular Location Endoplasmic reticulum membrane, Single-pass type II membrane protein, SUBCELLULAR LOCATION: Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus
Protein Families BZIP family, ATF subfamily
Tissue Specificity Ubiquitous.
Database Links

HGNC: 791

OMIM: 605537

KEGG: hsa:22926

STRING: 9606.ENSP00000356919

UniGene: Hs.492740

Pathway Protein processing in endoplasmic reticulum
Cell ageing and metabolism

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