Recombinant Human Lysosome-associated membrane glycoprotein 1(LAMP1)

Code CSB-CF012738HU
Size Pls inquire
Source in vitro E.coli expression system
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Product Details

Target Names LAMP1
Uniprot No. P11279
Alternative Names CD107 antigen like family member A; CD107 antigen-like family member A; CD107a; CD107a antigen; LAMP 1 ; LAMP-1; LAMP1; LAMP1_HUMAN; LAMPA; LGP120 ; lgpA; Lysosomal membrane glycoprotein 120KD; Lysosomal Associated Membrane Protein 1 ; Lysosome associated membrane glycoprotein 1; Lysosome-associated membrane glycoprotein 1; Lysosome-associated membrane protein 1; OTTHUMP00000040663
Species Homo sapiens (Human)
Expression Region 29-417
Target Protein Sequence AMFMVKNGNGTACIMANFSAAFSVNYDTKSGPKNMTFDLPSDATVVLNRSSCGKENTSDPSLVIAFGRGHTLTLNFTRNATRYSVQLMSFVYNLSDTHLFPNASSKEIKTVESITDIRADIDKKYRCVSGTQVHMNNVTVTLHDATIQAYLSNSSFSRGETRCEQDRPSPTTAPPAPPSPSPSPVPKSPSVDKYNVSGTNGTCLLASMGLQLNLTYERKDNTTVTRLLNINPNKTSASGSCGAHLVTLELHSEGTTVLLFQFGMNASSSRFFLQGIQLNTILPDARDPAFKAANGSLRALQATVGNSYKCNAEEHVRVTKAFSVNIFKVWVQAFKVEGGQFGSVEECLLDENSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Data

Function Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.; FUNCTION
Gene References into Functions
  1. LIN28A inhibits lysosomeassociated membrane glycoprotein 1 protein expression in embryonic stem and bladder cancer cells. PMID: 29749495
  2. A novel data on LAMP-1 overexpression in high grade glioma are presented suggesting involvement of this gene and protein in cell adhesion and tumor progression. PMID: 29920782
  3. LAMP1 is involved in the TNM stages and histological differentiation of the esophageal squamous cell carcinoma PMID: 28687162
  4. LAMP1 has a role in fratricide amongst T cell receptor transgenic CD8+ T cells directed against tumor-associated antigens PMID: 27447745
  5. Impaired autophagic pathways were further shown by analyzing late autophagic vesicles; immunostaining with lysosome-associated membrane protein 1 (LAMP-1) antibody revealed enlarged and annular LAMP-1-positive organelles in AMD retinal pigment epithelium (RPE)as opposed to smaller discrete puncta observed in normal RPE PMID: 28055007
  6. The authors show here that human LAMP1 and LAMP2 bind cholesterol in a manner that buries the cholesterol 3beta-hydroxyl group; they also bind tightly to NPC1 and NPC2 proteins that export cholesterol from lysosomes. PMID: 27664420
  7. downregulation of FUT1, which leads to the perinuclear localization of LAMP-1 and 2, is correlated with increased rate of autophagic flux by decreasing mTOR signaling and increasing autolysosome formation. PMID: 27560716
  8. the assembly modes of LAMP-1 and LAMP-2 are different, which may underlie their distinct functions PMID: 27663661
  9. Overexpression of LAMP1 was observed in prostate cancer (PCa) and castration-resistant prostate cancer clinical specimens. Moreover, downstream pathways were identified using si-LAMP1-transfected cells. The discovery of tumor-suppressive miR320a-mediated pathways may provide important insights into the potential mechanisms of PCa metastasis. PMID: 27212625
  10. The data implied that high LAMP1 expression is associated with unfavourable prognosis in laryngeal squamous cell carcinoma patients, and LAMP1 may be identified as a novel prognostic biomarker PMID: 27788920
  11. The data support a viral entry mechanism dependent on binding to the lysosome-resident receptor LAMP1 and further dissociation of the membrane-distal GP1 subunits. PMID: 26849049
  12. A unique triad of histidines of Lassa Virus GP1 forms a binding site for host LAMP1. PMID: 25972533
  13. The LAMP-1 had preferential localization in the high density secondary lysosomes where endogenous human LAMP-1 was enriched. In contrast, a major portion of I382L was located in a low density fraction. PMID: 24695761
  14. Downregulation of miR-184 was consistent with significantly lower levels of LAMP-1 PMID: 25251993
  15. Synergistic defects of different molecules in the cytotoxic pathway lead to clinical familial hemophagocytic lymphohistiocytosis. PMID: 24916509
  16. Caveolin-1 associated adenovirus entry into human corneal cells. PMID: 24147000
  17. study has shown that Lassa virus entry requires a pH-regulated engagement of alpha-DG and LAMP1 both of which need to be glycosylated PMID: 24970085
  18. in TB pleurisy regulatory T lymphocytes effectively inhibit CD107a expression PMID: 24134738
  19. LAMP-1 and LAMP-2 could be used as additional markers with which to assess enzyme replacement therapy effectiveness in Fabry disease. PMID: 24334114
  20. LAMP-1/GFAP showed pronounced co-expression and LAMP-1/CD133 was co-expressed as well in astrocytomas suggesting that tumor cells including the proposed tumor stem cells contain lysosomes. PMID: 23826410
  21. CD107a/LAMP-1 has a role in the protection of NK cells from degranulation-associated suicide PMID: 23847195
  22. Data indicate that monoclonal antibodies specific to CD107a (LAMP-1) or CD107b (LAMP-2) enhanced LPS-induced IL-8 secretion of THP-1 cells. PMID: 23603048
  23. LAMP1 is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity. PMID: 23632890
  24. Simultaneous expression of LAMP1 and EGFR correlates with the ovarian neoplasm grading. PMID: 23172893
  25. LAMP proteins retain TAPL on the limiting membrane of endosomes and prevent its sorting to intraluminal vesicles. PMID: 22641697
  26. Data indicate that lysosomally targeted cameleon Ca2+ probe LAMP1-YCaM accurately and sensitively responds to both global and lysosome-specific Ca2+ signals. PMID: 23098255
  27. Report expression of NKG2D and CD107 in CD8(+) effector memory lymphocytes in Churg-Strauss syndrome. PMID: 22640649
  28. nucleolin and LAMP-1 have a role in promoting infection of human monocytes by Francisella tularensis PMID: 21152024
  29. Human full-length amelogenin increases the proliferation of mesenchymal stem cells by interaction with LAMP1 through the MAPK-ERK signaling pathway. PMID: 20967466
  30. Immunohistochemistry studies showed EGBs to exhibit pronounced reactivity to antibodies against lysosome-associated membrane proteins (LAMP)-1 and LAMP-2, and the lysosomal enzyme cathepsin D. PMID: 20926008
  31. review of structure, function, cell and tissue distribution, intracellular trafficking PMID: 12144129
  32. This study identifies two cDNA clones that code for heart extracellular matrix protein, hLAMP-1. Immunohistochemical studies indicate that the myocardial layer of the heart produces hLAMP-1. PMID: 15052658
  33. Using human leukemia and lymphoma cell lines, we observed a close correlation between CD107a surface expression and target cell lysis, indicating that NK cell cytotoxicity can be assessed by this method. PMID: 15744340
  34. Data identify CD13, CD107a, and CD164 as novel basophil-activation antigens. PMID: 15916720
  35. Novel evidence for differential expression of HBGA and LAMPs in proliferative and involutive phases of immunohistochemistry is presented. PMID: 16570122
  36. expression in keratinocytes cultured at different cell densities in order to induce differentiation PMID: 16710742
  37. Enhanced expression of lysosome-associated membrane protein-1 in melanoma may promote invasion by influencing both adhesion to extracellular matrix and perhaps also binding to endothelial cells. PMID: 16718270
  38. CD107a surface expression has a role in Munc13-4 defect in familial hemophagocytic lymphohistiocytosis PMID: 16778144
  39. LAMP-1 and DC-LAMP antigen chimeras follow different trafficking pathways, induce distinct modulatory immune responses, and are able to present cryptic epitopes. PMID: 16887987
  40. LAMP-1 and LAMP-2 may have roles in accidental involution of the thymic gland PMID: 17048695
  41. Data show that cells lacking either LAMP-1 or LAMP-2 alone formed phagosomes that gradually acquired microbicidal activity and curtailed bacterial growth, but LAMP-1 and LAMP-2 double-deficient cells failed to kill engulfed Neisseria gonorrhoeae. PMID: 17506821
  42. CD107a expression may be a sensitive marker for the cytotoxic activity determination PMID: 18835598
  43. Despite its abundance, LAMP-1 is not essential, but LAMP-2 may be partially important for the Salmonella-containing vacuolar membrane. PMID: 18958159
  44. the activation-induced degranulation of Fas ligand has distinct requirements and involves different mechanisms than those of the granule markers CD63 and CD107a/Lamp-1 PMID: 19079288
  45. Most Hassal's corpuscules in thymoma were negative for LAMPs, but positive in normal thymus. Both lymphocytes and epithelial cells in pathological thymus showed higher intensity for LAMP-2 compared with LAMP-1. PMID: 19343823
  46. Data show that The cell surface expression levels of (ICAM)-2 and -3 on the apoptotic cells were markedly lower, while those of calnexin, calreticulin, and (LAMP)-1 and -2 were significantly higher compared to non-apoptotic cells. PMID: 19524015

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Subcellular Location Cell membrane, Single-pass type I membrane protein, Endosome membrane, Single-pass type I membrane protein, Lysosome membrane, Single-pass type I membrane protein, Late endosome
Protein Families LAMP family
Database Links

HGNC: 6499

OMIM: 153330

KEGG: hsa:3916

STRING: 9606.ENSP00000333298

UniGene: Hs.494419

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