Code | CSB-CF002766MO |
MSDS | |
Size | $1620 |
Order now | |
Image | |
Have Questions? | Leave a Message or Start an on-line Chat |
This recombinant MouseBnip3 protein is an in vitro E.coli (cell-free) expressed Full Length protein. Its purity is 85%+ determined by SDS-PAGE. Cell-free protein expression is the in vitro synthesis of a protein using translation-compatible extracts of whole cells. In principle, whole-cell extracts contain all the macromolecules and components needed for transcription, translation, and even post-translational modification. These components include RNA polymerase, regulatory protein factors, transcription factors, ribosomes, and tRNA. When supplemented with cofactors, nucleotides, and the specific gene template, these extracts can synthesize proteins of interest in a few hours.
Bnip3, a pro-apoptotic BH3-only protein of the Bcl-2 family, is involved in apoptosis, programmed necrosis, autophagy, and mitophagy in the process of cells and tissues exposed to hypoxia or ischemia. In addition to involvement in cell death and metastasis-associated processes, Bnip3 can also regulate different metabolic pathways, such as lipid metabolism, glycolysis, and mitochondrial bioenergetics. Bnip3 also plays a critical role in carcinogenesis. Upregulated expression of Bnip3 has been reported in lung, prostate, cervical tumors, and breast cancers. Increased Bnip3 expression has been linked to the aggressive tumor phenotype and a dismal prognosis.There are currently no reviews for this product.