BNIP3

BNIP3 (BCL2/adenovirus E1B 19 kDa protein-interacting protein 3) is a pro-apoptotic BCL2 family member, also known as NIP3. Localized to the mitochondrial outer membrane, it induces mitochondrial outer membrane permeabilization (MOMP) via channel formation, releasing cytochrome c to activate caspase-dependent apoptosis. It also interacts with LC3 to mediate mitophagy, clearing dysfunctional mitochondria.
Upregulated through the hypoxia-inducible factor (HIF) pathway under hypoxic conditions, BNIP3 is linked to cancer (downregulation in colorectal/breast tumors supports survival) and neurodegenerative disorders (mitophagy defects in Parkinson’s). Preclinical studies explore compounds targeting BNIP3 to enhance cancer cell apoptosis or improve mitophagy in neurodegeneration.

Popular Product:

BNIP3 Antibody (CSB-PA618642ESR1HU)

Validated Data

Immunohistochemistry of paraffin-embedded human prostate tissue using CSB-PA618642ESR1HU at dilution of 1:100

Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA618642ESR1HU at dilution of 1:100

Immunofluorescent analysis of MCF-7 cells using CSB-PA618642ESR1HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

The following BNIP3 reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

BNIP3 Antibodies

BNIP3 Proteins

BNIP3 Antibodies

BNIP3 Antibodies for Homo sapiens (Human)

Code	Product Name	Species Reactivity	Application
CSB-PA618642ESR1HU	BNIP3 Antibody	Human	ELISA, IHC, IF
CSB-PA004979	BNIP3 Antibody	Human	WB, ELISA
CSB-PA050118	BNIP3 Antibody	Human,Mouse,Rat	WB, IHC, ELISA
CSB-PA093779	BNIP3 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-PA084239	BNIP3 Antibody	Human,Mouse	ELISA,WB,IHC
CSB-RA552618A0HU	BNIP3 Recombinant Monoclonal Antibody	Human	ELISA, WB, IHC, FC

BNIP3 Antibodies for Mus musculus (Mouse)

Code	Product Name	Species Reactivity	Application
CSB-PA002766ZA01MO	Bnip3 Antibody	Mus musculus	ELISA, WB (ensure identification of antigen)

BNIP3 Proteins

BNIP3 Proteins for Mus musculus (Mouse)

Code	Product Name	Source
CSB-CF002766MO	Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3)	in vitro E.coli expression system
CSB-EP002766MO1	Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), partial	E.coli
CSB-YP002766MO1 CSB-BP002766MO1 CSB-MP002766MO1 CSB-EP002766MO1-B	Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), partial	Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli
CSB-CF002766MO2	Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3), partial	in vitro E.coli expression system
CSB-MP002766MO	Recombinant Mouse BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3)-VLPs	Mammalian cell

BNIP3 Proteins for Homo sapiens (Human)

Code	Product Name	Source
CSB-CF618642HU	Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	in vitro E.coli expression system
CSB-YP618642HU1 CSB-EP618642HU1 CSB-BP618642HU1 CSB-MP618642HU1 CSB-EP618642HU1-B	Recombinant Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

BNIP3 Proteins for Bos taurus (Bovine)

Code	Product Name	Source
CSB-CF656958BO	Recombinant Bovine BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)	in vitro E.coli expression system
CSB-YP656958BO1 CSB-EP656958BO1 CSB-BP656958BO1 CSB-MP656958BO1 CSB-EP656958BO1-B	Recombinant Bovine BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3), partial	Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli

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Popular Pathways

Apoptosis

Breast Cancer

Autophagy

Hippo Signaling Pathway

Wnt Signaling Pathway

Hippo signaling pathway

TGF-beta signaling pathway

Apoptosis mediated by mitochondria The Overview of Hippo Signaling Pathway The Overview of Autophagy Crosstalk Between Autophagy and Apoptosis The Overview of Wnt Signaling Pathway The Overview of Breast Cancer: Related Signaling Pathways, Therapeutic Targets The overview of TGF-β signaling pathway PI3K-Akt Signaling Pathway and Cancer Apoptosis mediated by endoplasmic reticulum Apoptosisi mediated by death receptor Aesthetic Appreciation of Apoptosis Signal Pathway An Overview of Cell Death: Necrosis and Apoptosis Do You Really Know TGF-β Superfamily? Double-Edged Sword: TGF-β The Overview of PI3-Alt Signaling Pathway How to Inquire and Utilize the Signal Pathway on KEGG LPS/TLR4 Signal Transduction Pathway Epigenetic Histone Modifications Pathway What A Paradoxical TNF Signaling Pathway-Based on Different Receptors The Overview of Fc Receptors- Classification, Related Signaling Pathways and Application