Recombinant Human Tumor necrosis factor receptor superfamily member 1A protein(TNFRSF1A) (Active)

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Code CSB-AP002361HU
Product Type Tumor Necrosis Factor
Size US$112Purchase it in Cusabio online store
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Uniprot No. P19438
Lead Time 5-10 business days
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Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias Tumor necrosis factor receptor 1, Tumor necrosis factor receptor type I, TNF-RI, TNFR-I, p55
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit the TNF-alpha mediated cytotoxicity in the L-929 cells is less than 0.05 μg/ml, corresponding to a specific activity of >2x104 IU/mg in the presence of 0.25 ng/mL of rHuTNF-alpha.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence IYPSGVIGLV PHLGDREKRD SVCPQGKYIH PQNNSICCTK CHKGTYLYND CPGPGQDTDC RECESGSFTA SENHLRHCLS CSKCRKEMGQ VEISSCTVDR DTVCGCRKNQ YRHYWSENLF QCFNCSLCLN GTVHLSCQEK QNTVCTCHAG FFLRENECVS CSNCKKSLEC TKLCLPQIEN VKGTEDSGTT
Research Area Cancer
Source E.coli
Gene Names TNFRSF1A
Expression Region 22-211aa
Tag Info Tag-Free
Mol. Weight 21.2 kDa
Protein Description Partial
PubMed ID 2158862; 2158863; 1702293; 1698610; 2170974; 1315717; 14702039; 19906316; 16541075; 15489334; 8015639; 2153136; 9557650; 10356400; 10542291; 10359574; 9915703; 15465831; 21976655; 22801493; 8387891; 8939750; 10199409; 10902757; 11443543; 13130484; 1461067
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Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Involvement in disease Familial hibernian fever (FHF); Multiple sclerosis 5 (MS5)
Subcellular Location Cell membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Secreted, Note=A secreted form is produced through proteolytic processing, SUBCELLULAR LOCATION: Isoform 4: Secreted
Database Links

HGNC: 11916

OMIM: 142680

KEGG: hsa:7132

STRING: 9606.ENSP00000162749

UniGene: Hs.279594

Pathway MAPK signaling pathway
mTOR signaling pathway
NF-kappa B signaling pathway
TNF signaling pathway
Apoptosis
Necroptosis
Osteoclast differentiation
Adipocytokine signaling pathway

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