TNFRSF1A Antibody

Datasheet
Code CSB-PA973584
Product Type Polyclonal Antibody
Size US$297
Uniprot No. P19438
Image
  • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TNF receptor-1 antibody.
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Synthesized peptide derived from Internal of Human TNF receptor-1.
Raised in Rabbit
Species Reactivity Human,Mouse
Specificity The antibody detects endogenous levels of total TNF receptor-1 protein.
Tested Applications ELISA,IHC;IHC:1:50-1:100
Relevance Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.

Jennifer Adjodha, AACR Meeting Abstracts, Apr 2006; 2006: 1028.
Kewu Huang, J Appl Physiol, Apr 2007; 102: 1632 - 1639.
Kiyoshi Asada, AACR Meeting Abstracts, Apr 2005; 2005: 202.
Elaine K Green, J. Med. Genet., Aug 2000; 37: 581.
Form Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality Polyclonal
Alias CD120a; TBPI; TNF-RI; TNFAR; TNFR1
Immunogen Species Homo sapiens (Human)
Target Names TNFRSF1A
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Involvement in disease Familial hibernian fever (FHF); Multiple sclerosis 5 (MS5)
Subcellular Location Cell membrane, Single-pass type I membrane protein, Golgi apparatus membrane, Single-pass type I membrane protein, Secreted, Note=A secreted form is produced through proteolytic processing, SUBCELLULAR LOCATION: Isoform 4: Secreted
Database Links

HGNC: 11916

OMIM: 142680

KEGG: hsa:7132

STRING: 9606.ENSP00000162749

UniGene: Hs.279594

Pathway MAPK signaling pathway
mTOR signaling pathway
NF-kappa B signaling pathway
TNF signaling pathway
Apoptosis
Necroptosis
Osteoclast differentiation
Adipocytokine signaling pathway

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