Recombinant Mouse Tumor necrosis factor receptor superfamily member 10B(Tnfrsf10b),partial

In Stock
Code CSB-AP005041MO
Product Type Tumor Necrosis Factor
Size US$124
Uniprot No. Q9QZM4
Lead Time 5-10 business days
Storage Buffer Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.4
Alias Tumor necrosis factor receptor superfamily member 10B/Death receptor 5/MK/CD262/Tnfrsf10b/Dr5/Killer
Species Mus musculus (Mouse)
Biological_Activity The ED50 as determined by its ability to inhibit TRAIL-mediated cytotoxicity using L?929 mouse fibroblast cells treated with TRAIL is less than 1 ug/ml.
Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Cancer
Source Mammalian cell
Gene Names Tnfrsf10b
Expression Region 53-177aa
Tag Info C-terminal FC-tagged
Mol. Weight 40.9 kDa
Protein Description Partial
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Function Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Subcellular Location Membrane, Single-pass type I membrane protein
Tissue Specificity Highly expressed in heart, lung and kidney.
Database Links

KEGG: mmu:21933

STRING: 10090.ENSMUSP00000022663

UniGene: Mm.193430

Pathway p53 signaling pathway
Natural killer cell mediated cytotoxicity

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