TNFRSF10B

TNFRSF10B Background

Tumor necrosis factor receptor superfamily member 10B is a protein in humans that is encoded by the TNFRSF10B gene. It is a member of the TNF-receptor superfamily and contains an intracellular death domain. TNFRSF10B is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. This receptor can be activated by tumor necrosis factor-related apoptosis-inducing ligand (TNFSF10/TRAIL/APO-2L) and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain-containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. It also promotes the activation of NF-kappa-B. And it is essential for ER stress-induced apoptosis.