The following TNFRSF10B reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.

TNFRSF10B Antibodies

TNFRSF10B Antibodies for Homo sapiens (Human)

TNFRSF10B Proteins

TNFRSF10B Proteins for Mus musculus (Mouse)

TNFRSF10B Proteins for Homo sapiens (Human)


TNFRSF10B ELISA Kit for Homo sapiens (Human)

TNFRSF10B Background

Tumor necrosis factor receptor superfamily member 10B is a protein in humans that is encoded by the TNFRSF10B gene. It is a member of the TNF-receptor superfamily and contains an intracellular death domain. TNFRSF10B is a receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. This receptor can be activated by tumor necrosis factor-related apoptosis-inducing ligand (TNFSF10/TRAIL/APO-2L) and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain-containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. It also promotes the activation of NF-kappa-B. And it is essential for ER stress-induced apoptosis.

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