TNFRSF10B

TNFRSF10B, tumour necrosis factor receptor superfamily member 10B, is also known as death receptor 5 (DR5). It is a cell surface receptor expressed mainly in a variety of tissues, especially at high levels in tumour cells.The mechanism of action of TNFRSF10B is to trigger the apoptotic signalling pathway by binding to tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). The signalling pathway involves the aggregation of death structural domains (DDs) upon binding of TRAIL to TNFRSF10B, which in turn recruits Fas-associated death structural domain proteins (FADDs) and initiates the caspase cascade reaction, especially the activation of caspase-8, leading to programmed cell death.TNFRSF10B plays a key role in regulating the balance between cell survival and death. Its specific role in tumour cell apoptosis makes it a promising target for cancer therapy and contributes to the development of new targeted therapeutic strategies to enhance the sensitivity of tumour cells to apoptosis.