Thank you for supporting CUSABIO! Our products were cited in 455 publications for this quarter, with a impact factor of 2356.7842! These publications show that our products are reliable and trusted by our customers. By using CUSABIO's reagents, you can expect better support for your experiments and more opportunities to publish great work. Let's explore together the impressive scientific advancements with CUSABIO products.
Impact Factor: 38.104
Journal Name: Signal transduction and targeted therapy
Author's Affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College(Saisai Guo)
DOI: 10.1038/s41392-022-01239-w
CUSABIO Citation Product: Recombinant Severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase(NSP12)
The author via a mass spectrometry (MS)-based proteomic approach identified host proteins associated with non-structural protein 12 (nsp12), the RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2. CDK2, a member of the cyclin-dependent kinase family, was found to interact with nsp12 and phosphorylate it at the T20 site, promoting assembly of the RdRp complex and efficient synthesis of viral RNA. Inhibitors of CDK2 were found to impair viral RNA synthesis and SARS-CoV-2 infection, making CDK2 a potential target for developing RdRp inhibitors against SARS-CoV-2.
Impact Factor: 33.883
Journal Name: Gastroenterology
Author's Affiliation: Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China(Ziyu Yang)
DOI: 10.1053/j.gastro.2023.02.046
CUSABIO Citation Product:
Human Interleukin 1β,IL-1β ELISA Kit
Human growth-regulated oncogeneα/melanoma growth stimulating activity,GROα/MGSA ELISA Kit
This study found that a specific genotype (ST54) of Clostridioides difficile (CDI) is more prone to infect patients with inflammatory bowel disease (IBD) than the prevalent ST81 genotype, exacerbating their inflammation response. By gene knockout to construct an IBD animal model, researchers discovered that ST54 infection caused more severe inflammation in IBD mice.
The study also found higher sorbitol levels in IBD patient feces than in healthy controls, which may be one of the reasons promoting ST54 infection. The results suggest that controlling high-sorbitol diets or reducing intestinal sorbitol levels could effectively reduce the incidence and severity of CDI in IBD patients.
Impact Factor: 31.793
Journal Name: Gut
Author's Affiliation: Medical University of Vienna(Tim Hendrikx)
DOI: 10.1136/gutjnl-2022-328265
CUSABIO Citation Product:Mouse Lipopolysaccharides(LPS) ELISA Kit
In patients with alcohol-related hepatitis, the levels of pIgR and IgA in liver increase. Using pIgR-deficient mice, the study revealed that these mice were more susceptible to liver injury, inflammation, and steatosis following ethanol ingestion. Furthermore, pIgR-deficient mice had higher plasma endotoxin levels and more hepatic bacteria, indicating bacterial translocation. Non-absorbable antibiotic treatment of pIgR-/- mice prevented ethanol-induced liver disease. The study suggests that dysfunctional hepatic pIgR enhances alcohol-associated liver disease due to impaired antimicrobial defence by IgA in the gut.
Impact Factor: 28.213
Journal Name: Nature cell biology
Author's Affiliation: Lerner Research Institute, Cleveland Clinic(Shin-Ae Lee)
DOI: 10.1038/s41556-022-01039-y
CUSABIO Citation Product:Recombinant Mouse Mixed lineage kinase domain-like protein(Mlkl)
The study focused on Necroptosis, a cell death process mediated by RIPK3-ZBP1-MLKL. OASL, an antiviral protein, was found to form a platform through liquid-liquid phase separation to recruit RIPK3 and ZBP1. This led to RIPK3 activation and MLKL phosphorylation, resulting in Necroptosis. Mice without Oasl1 are vulnerable to viral infections and have weakened immune function. The study suggests that OASL builds the non-classical death complex of RIPK3-ZBP1 via its phase-separated droplets, boosting the host's immune response against viruses.
Impact Factor: 22.096
Journal Name: Cellular & molecular immunology
Author's Affiliation: Cellular & molecular immunology
DOI: 10.1038/s41423-023-00985-3
CUSABIO Citation Product:
Human Interleukin 6,IL-6 ELISA KIT
Human Interleukin 10,IL-10 ELISA KIT
Human interferon γ(IFN-γ) antibody ELISA kit
Human Interferon β,IFN-β/IFNB ELISA Kit
The author developed a CAR-T cell model for COVID-19 and discovered that Felodipine, Fosinopril, Imatinib, and Carprofen could inhibit cytokine release in vitro. These drugs improved pneumonia, reduced inflammation, and prevented death in mouse models. They are safe, cheap, and easily obtainable with great potential for early COVID-19 treatment. The author also created a high-throughput CAR-T cell model for screening anti-inflammatory drugs, providing a better solution for treating COVID-19.
Impact Factor: 20.693
Journal Name: Journal of medical virology
Author's Affiliation: Sun Yat-sen University(Heping Zhao)
DOI: 10.1002/jmv.28674
CUSABIO Citation Product:
Human Lipopolysaccharides,LPS ELISA Kit
Human lipolysaccharide binding protein,LBP ELISA Kit
Human soluble cluster of differentiation 14,sCD14 ELISA Kit
The author discusses the relationship between gut microbiota and immune responses in MSM HIV-infected patients receiving antiretroviral therapy. Results show changes in gut microbiota composition, with decreases in Coprococcus, Blautia, Clostridium, and SMB53, and increases in Megamonas and Megasphaera in PLHIV. In addition, sCD14 levels were elevated in both treated and untreated groups compared to healthy controls. These findings may aid in developing new treatment strategies to improve immune response and quality of life in PLHIV.
Impact Factor: 17.694
Journal Name: Nature communications
Author's Affiliation: School of Life Sciences, Yunnan University(Nan Wu)
DOI: 10.1038/s41467-023-35899-1
CUSABIO Citation Product: NFE2L2 Monoclonal Antibody
The activation of the sulfur metabolic pathway was found to be linked to both peroxisome function and gene expression by the author's study on the long-lived glp-1(e2141ts) mutant of Caenorhabditis elegans. Supplementation of alpha-ketobutyrate, a metabolite of this pathway, increased the lifespan of wild-type worms by regulating LDH-1 and activating SIR-2.1/SIRT1-mediated peroxisome function and ACOX1 expression. α-ketobutyrate also delayed cellular senescence via the SIRT1-ACOX1-H2O2-NRF2 pathway. These findings reveal the novel role of α-ketobutyrate in biological health and lifespan.
Impact Factor: 15.304
Journal Name: Biomaterials
Author's Affiliation: Xijing Hospital, Fourth Military Medical University(Hao Wu)
DOI: 10.1016/j.biomaterials.2022.121990
CUSABIO Citation Product: ATP5F1A Antibody
The researchers developed a new material, BT/Ti scaffold, for bone reconstruction. Polarized BT/Ti scaffolds induced piezoelectric effects, promoting M2 polarization and osteogenesis of macrophages. LIPUS stimulation increased CD68+CD206+ M2 macrophages, facilitating bone regeneration. Polarization suppressed oxidative phosphorylation (OXPHOS) and activated ATP synthesis. The study proposed a novel technical solution for bone tissue repair via the piezoelectric effect of BT/Ti scaffolds.