As we bid farewell to 2023, CUSABIO remains committed to delivering top-notch products and innovative solutions to support researchers worldwide.
In the past year, CUSABIO products have been cited in over 2000 customer publications, accumulating an impressive impact factor surpassing 10,000+. These publications reflect the remarkable achievements of our customers and highlight the broad applications of CUSABIO products across diverse research fields.
We extend our gratitude for choosing CUSABIO as your research partner, and we look forward to continuing to provide excellent products and services. Cheers to the collective success of the scientific community in 2023!
Impact Factor: 64.8
Journal Name: Nature
CUSABIO Citation Product: Recombinant Drosophila melanogaster GEO11329p1 (ITP) (CSB-MP3350DLU)
This study reveals a novel tumor-kidney interaction mechanism. Specifically, tumor cells secrete ITPF, leading to the activation of G protein-coupled receptor TkR99D in renal cells. This activation inhibits renal excretory function, causing toxin accumulation and promoting tumor cell growth. This mechanism has been confirmed in various tumor types and mouse models, providing new insights for developing therapeutic strategies targeting ITPF.
Impact Factor: 64.8
Journal Name: Nature
CUSABIO Citation Product: Recombinant Human Endogenous retrovirus group K member 7 Env polyprotein(ERVK-7), CSB-CF351062HU
The study investigated lung-resident B cell responses in lung cancer patients and a mouse model. Both human and mouse lung adenocarcinomas triggered local germinal center reactions and anti-tumor antibodies, primarily targeting endogenous retroviruses (ERV). Effective immunotherapy in mouse models depended on the formation of tertiary lymphoid structures (TLS) requiring CXCL13. Additionally, therapeutic CXCL13 treatment enhanced anti-tumor immunity, synergizing with immune checkpoint blockade. These findings provide insights into the connection between TLS and immune therapy response.
Impact Factor: 64.5
Journal Name: Cell
CUSABIO Citation Product:Mouse Interferon γ ,IFN-γ ELISA Kit, CSB-E04578m
Previous studies focused on the impact of symbiotic bacteria in the colon on immune tolerance, overlooking the mechanisms of food immune tolerance. This study uncovers that food antigens induce immune tolerance by maintaining regulatory T cells in the intestinal tract. Food antigen-specific T cells act as a subset of regulatory T cells with anti-inflammatory functions. Intestinal epithelial cells (IECs) in the upper small intestine were found to accumulate an unexpected 13 kD GSDMD fragment in response to proteinaceous food antigen stimulation. This GSDMD fragment translocates to the nucleus, promoting the transcription of CIITA and MHCII molecules, thereby supporting the maintenance of food immune tolerance by inducing type 1 regulatory T cells.
Impact Factor: 50.3
Journal Name: Cancer cell
CUSABIO Citation Product: Mouse Lipopolysaccharides(LPS) ELISA Kit,CSB-E13066m
Colorectal cancer (CRC) is a common and lethal malignancy. Alterations in the gut microbiota play a pivotal role in influencing the occurrence and progression of CRC. The intake of probiotics or their metabolites, which are deficient in the body, has been proven to be an effective therapeutic approach for CRC. A study led by Professor Jun Yu's team at the Chinese University of Hong Kong identified a probiotic, C. maltaromaticum, capable of influencing the progression of colorectal cancer. It was found to inhibit the occurrence and development of CRC in female patients in an estrogen-dependent manner through the SLC3A2-VDR signaling pathway, offering a novel avenue for the treatment of colorectal cancer.
Impact Factor: 44.1
Journal Name: Cell research
CUSABIO Citation Product: Mouse interleukin-18 binding prorein(IL-18BP) ELISA Kit,CSB-E17797m
The study reveals the crucial role and mechanism of a long non-coding RNA (lncRNA) associated with inflammatory bowel disease (IBD), providing significant insights into understanding the mechanisms underlying the maintenance of intestinal homeostasis and protection against colitis. It represents the first description of the impact of the IBD-associated long non-coding RNA (CARINH) in protecting against inflammatory bowel disease. Genetic studies indicate that the T allele at the rs2188962 locus in the human CARINH region may be the most likely pathogenic variant contributing to inflammatory bowel disease. The research elucidates how IBD-associated long non-coding RNAs maintain intestinal homeostasis and protect the host against colitis.
Impact Factor: 44.1
Journal Name: Cell research
CUSABIO Citation Product: Human cathepsin B (CTSB) ELISA kit, CSB-E13450h
This study reveals that S-nitrosylation of Cathepsin B, a cysteine protease, selectively affects the adenosine (A) to inosine (I) editing of its own mRNA. The unique protein expression regulation is governed by the ADD1/MATR3/ADAR1 axis, termed "Protein-guided ADAR1 Editing of its Own mRNA" (PEDORA). This introduces an additional layer of understanding in protein expression regulation, representing a mechanism in eukaryotic gene expression control that was previously undisclosed. The research elucidates a novel reverse information transfer mechanism in post-transcriptional regulation of mRNA by a protein's post-translational modification.
Impact Factor: 39.3
Journal Name: Signal transduction and targeted therapy
CUSABIO Citation Product: Recombinant Severe acute respiratory syndrome coronavirus 2 RNA-dependent RNA polymerase (NSP12), CSB-EP3371GND
Amidst the COVID-19 pandemic, discovering host factors crucial for SARS-CoV-2 RNA replication is key. Using mass spectrometry, the authors identified Cyclin-Dependent Kinase 2 (CDK2) as a host protein interacting with the virus's RNA-dependent RNA polymerase (RdRp) non-structural protein 12 (nsp12). This interaction phosphorylates nsp12 at the T20 site, promoting assembly of the RdRp complex and facilitating efficient viral RNA synthesis. This research sheds light on potential cellular targets for broad-spectrum antiviral drug development.
Impact Factor: 39.3
Journal Name: Signal transduction and targeted therapy
CUSABIO Citation Product:
Mouse very low density lipoprotein(VLDL)ELISA Kit,CSB-E17089m
Mouse oxidized low density lipoprotein,OxLDL ELISA Kit,CSB-E07933m
Natriuretic Peptide Receptor C (NPRC) has demonstrated beneficial effects in cardiovascular diseases in animal models, yet its role in atherosclerosis remains unclear. NPRC deletion, by modulating the cAMP/PKA-AKT1 and NF-κB pathways, reduces inflammation and endothelial cell apoptosis, enhances eNOS expression, and decreases the size and instability of atherosclerotic lesions. Targeting NPRC presents a promising avenue for preventing and treating atherosclerosis.
Impact Factor: 32.4
Journal Name: Immunity
CUSABIO Citation Product: LUM Antibody,CSB-PA013234ESR1HU
This study sheds light on the early stages of lymph node (LN) formation, where lymphoid tissue organizer cells (LTo) and lymphoid tissue inducer cells (LTi) coordinate strategically during development. The research identifies Osr1-expressing cells as precursors to mesenchymal LTo cells through lineage tracing. By exploring the heterogeneity of Osr1+ cells, distinct characteristics of mesenchymal LTo cells at different locations are revealed, establishing a common origin for mesenchymal LTos and LN-associated adipose tissue. The findings redefine the role and identity of mesenchymal tissue-forming cells, presenting a collaborative cellular model to better understand LN formation.
Impact Factor: 32.4
Journal Name: Immunity
CUSABIO Citation Product: Recombinant Clostridium perfringens Perfringolysin O(pfo),CSB-EP314820CMB
The immunogenicity of the Ply427-444 epitope is determined by a conserved core region consisting of 11 amino acids (ECTGLAWEWWR), enabling cross-recognition of membrane-bound lytic proteins from heterologous bacterial pathogens. The study reveals that HLA-DP4-Ply427-441 functions similarly on private and public T-cell receptors (TCRs). These findings uncover the mechanistic determinants of nearly global immune responses focused on cross-border bacterial epitopes, holding significant implications for devising complementary strategies against life-threatening infectious diseases, including invasive pneumococcal infections.