CUSABIO Monthly Citation Review: 260 New Product Citations in October, Total Citations Hit 28,500!

This study reveals a novel role of adrenomedullin 2 (ADM2), produced by enteric neurons, in promoting the tissue-protective functions of group 2 innate lymphoid cells (ILC2s) and limiting intestinal inflammation. Genomic deletion of ADM2 receptor subunits in ILC2s significantly reduces tissue-protective ILC2 responses and amphiregulin (AREG) production, increasing susceptibility to intestinal damage and inflammation. Conversely, therapeutic delivery of recombinant ADM2 induces AREG+ protective ILC2s and limits intestinal inflammation. Moreover, expression of ADM2 receptor genes is altered in patients with inflammatory bowel diseases, correlating with reduced AREG expression in ILC2s.

In obese adults aged 65-85, intensive lifestyle intervention (diet plus aerobic/resistance exercise) preserved bone quality despite BMD loss: distal tibia cortical thickness and hip failure load remained stable, while spinal strength, trabecular bone score and bone material strength index improved, along with reduced inflammation, supporting safe weight control in later life./p>

Employing mtDNA fragmentomics, we identified sepsis-specific cf-mtDNA breakages in RNR2 and COX2 (AUC 0.865), with COX2 severity linked to outcome, outperforming copy number. Mechanistically, reduced protein binding exposes sites to bacterial restriction enzymes, offering novel early diagnostic and prognostic biomarkers.

Single-cell analysis shows PDAC-secreted MDK binds β-cell SDC4, suppresses Ras signaling, reduces insulin, and drives PCAND; plasma MDK distinguishes T2DM, offering a new early detection biomarker.

Sepsis triggers spinal astrocytes to release TNF-α, causing necroptosis of thoracic GABAergic neurons, sympathetic hyperactivity and cardiac injury; activating α2A-AR on astrocytes with dexmedetomidine protects the heart, unveiling a novel heart-spinal-immune axis.

Podocyte GOLM1 is upregulated in diabetic nephropathy and worsens renal injury by binding EGFR to suppress PPARγ/AMPKα signaling, enhancing inflammation, oxidative stress and apoptosis; genetic deletion or neutralizing antibody ameliorates DN in mice, revealing a novel therapeutic target.

Researchers developed a coin-sized, $10 closed-loop artificial pancreas patch with dissolvable microneedle-microtube arrays and a low-power electroosmotic pump for continuous glucose monitoring and insulin delivery. Validated in diabetic rats and pigs for 3 days, it achieved glucose control comparable to commercial systems, offering an affordable, wearable solution for diabetes management.

FGF9 from osteocytes binds FGFR2 on preosteoblasts to suppress osteogenesis; mechanical stress reduces FGF9, promoting maxillary intramembranous bone formation. FGF9 overexpression impairs maxillary growth, uncovering a critical osteocyte-preosteoblast axis in mechanotransduction and offering new therapeutic targets for craniofacial anomalies.

Bufalin targets STK33 for degradation, disrupting STK33-CCAR1/β-catenin oncogenic signaling to curb TNBC proliferation, migration and patient-derived organoid growth, offering a novel therapeutic target and natural degrader for precision therapy.

This study introduces a titanium-encapsulated composite seed integrating 125I brachytherapy and self-regulated magnetic hyperthermia. It enables precise, direction-independent thermal control and effectively reverses radiation-induced immune evasion, significantly enhancing anticancer efficacy across multiple solid tumor models with favorable biosafety.