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NPL Antibody

Datasheet
Code CSB-PA015994GA01HU
Size $600
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Product Details

Uniprot No.
Q9BXD5
Target Names
NPL
Alternative Names
0610033B02Rik antibody; C112 antibody; C1orf13 antibody; Dihydrodipicolinate synthase antibody; Dihydrodipicolinate synthetase homolog 1 antibody; MGC149582 antibody; MGC61869 antibody; N-acetylneuraminate lyase antibody; N-acetylneuraminate pyruvate-lyase antibody; N-acetylneuraminic acid aldolase antibody; NAL antibody; NALase antibody; NPL antibody; NPL_HUMAN antibody; NPL1 antibody; RP11-249O6.1 antibody; Sialate lyase antibody; Sialate-pyruvate lyase antibody; Sialic acid aldolase antibody; Sialic acid lyase antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Human NPL
Immunogen Species
Homo sapiens (Human)
Isotype
IgG
Purification Method
Antigen Affinity purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
ELISA,WB,IF
Protocols
ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs
Antibody FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded. Experiments show the true substrate is aceneuramate (linearized Neu5Ac).
Gene References into Functions
  1. an NPL splice variant is mainly expressed in human liver, kidney and peripheral blood leukocytes PMID: 16147865
  2. 3D structure model of N-acetylneuraminate lyase from human (hNAL, EC 4.1.3.3) was created and refined PMID: 19057931
Subcellular Location
Cytoplasm.
Protein Families
DapA family, NanA subfamily
Tissue Specificity
Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte.
Database Links

HGNC: 16781

OMIM: 611412

KEGG: hsa:80896

STRING: 9606.ENSP00000258317

UniGene: Hs.496969

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