PPP3R1 Antibody

1. expression of PPP3R1 decreased respectively in psoriatic lesions and HaCaT cells. PMID: 29181737
2. The CnB 5I/5D variation was found to be significantly associated with CAD. The 5-base pair deletion results in increased serum calcineurin levels. PMID: 28827117
3. we report that exogenous CnB is taken up by cells in a time- and concentration-dependent manner via clathrin-dependent receptor-mediated internalization. Our findings further confirm that uptake is mediated by the TLR4/MD2 complex together with the co-receptor CD14 PMID: 27090571
4. CnB is a novel host-derived immunostimulatory factor, having a role as an agonist in monocytes, and specificity in TLR4 signaling through TRAF3 and TRAF6, in response to various agonists. PMID: 26471241
5. Data (including data from micro-dissected trophoblasts and trophoblastic BeWo cell line) suggest that microRNA-512-3p participates in placental function by targeting PPP3R1, encoding a regulatory subunit of calcineurin B. PMID: 24246042
6. Further evidence that specific variations in MAPT (rs3785883) and PPP3R1 (rs1868402) are associated with accelerated progression of Alzheimer's disease PMID: 23727081
7. Expression level of PPP3R1 and GATA4, and NFATC4 genes for transcription factors did not differ in studied subgroups of patients. PMID: 23888774
8. Pancreatic beta cells lacking Cnb1 fail to express genes revealed to be direct NFAT targets required for replication, insulin storage, and secretion. PMID: 22814600
9. These findings reveal a novel signaling pathway (CnB-CD11b-NF-kappaB-TRAIL) regulating TRAIL expression and may help to understand the roles of the calcineurin B subunit in the regulation of innate immunity. PMID: 22197822
10. immunostimulatory protein and acts as a vaccine adjuvant inducing protective cellular and humoral responses against pneumococcal infection PMID: 21722668
11. CnB M118K fails to enhance the activities of NF-AT and p53 induced by CnA in HeLa-s cells. PMID: 21910968
12. CNB binds to proteasome subunit alpha type 7 (PSMA7) and inhibits the transactivation activity of hypoxia-inducible factor-1alpha (HIF-1alpha) via the proteasome pathway. PMID: 21256111
13. these data imply novel functions of calcineurin and NF-kappaB for successful IS maturation. PMID: 17038582
14. Endothelin 1 (ET-1) activates calcineurin and causes nuclear translocation of NFATc1, implicating the pathway in the ET-1-mediated stimulation of osteoblasts. PMID: 17237284
15. IGF-1/PPP3R1 gene polymorphisms influence muscle phenotypic responses to strength training in both black and white older men and women. PMID: 17761791
16. No significant differences in calcineurin b expression was observed between patients with schizophrenia and normal controls PMID: 18343007
17. Overexpression of calcineurin B subunit enhances the oncogenic potential of HEK293 cells PMID: 18422742
18. Study found that although calcineurin/NFAT signalling pathway has an important, non-redundant role in the regulation of lymphocyte developmental checkpoints, it is not essential for the development of blood myeloid lineages. PMID: 18818667
19. CNB gene 5I/5D polymorphism is associated with the risk of left ventricular hypertrophy and physical performance of athletes. PMID: 18825932

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HGNC: 9317

OMIM: 601302

KEGG: hsa:5534

STRING: 9606.ENSP00000234310

UniGene: Hs.280604